Hiti Klaus, Walochnik Julia, Maria Haller-Schober Eva, Faschinger Christoph, Aspöck Horst
Department of Ophthalmology, University of Graz, Austria.
Cornea. 2006 May;25(4):423-7. doi: 10.1097/01.ico.0000214204.22200.7f.
This study was undertaken in order to determine the susceptibility of acanthamoebae to various contact lens disinfecting systems, with respect to type of disinfectant and exposure time.
Ten contact lens solutions, including one new system, were tested for their effectivities against cysts of three Acanthamoeba strains. Of main interest was an incubation time of 8 hours (overnight disinfection) and cyst quantities of 10 and 10, respectively.
Boston Advance (polyaminopropyl biguanide 0.0005%, chlorhexidine 0.003%) for the storage of rigid gas permeable contact lenses destroyed the cysts of all strains at either concentration within one hour of exposure. Meni Care Plus (polyhexamethylene biguanide 0.0005%) also destroyed 10 cysts of all strains, however, 10 cysts only of two strains within one hour; after an exposure time of 8 hours all cysts were killed. The disinfecting solutions for soft contact lenses did not kill 10 cysts of either strain after 8 hours of incubation time.
Two of the tested contact lens solutions (the ones for rigid gas permeable lenses) destroyed the cysts of all strains. One of these, containing a combination of two amoebicidal ingredients even after only one hour of exposure time.
本研究旨在确定棘阿米巴对各种隐形眼镜消毒系统的敏感性，涉及消毒剂类型和暴露时间。
测试了十种隐形眼镜护理液，包括一种新系统，评估它们对三种棘阿米巴菌株包囊的有效性。主要关注的是8小时的孵育时间（过夜消毒）以及分别为10个和10个的包囊数量。
用于储存硬性透气性隐形眼镜的Boston Advance（0.0005%聚氨基丙基双胍，0.003%洗必泰）在暴露一小时内，两种浓度下均可破坏所有菌株的包囊。Meni Care Plus（0.0005%聚六亚甲基双胍）在一小时内也能破坏所有菌株的10个包囊，但仅能破坏两种菌株的10个包囊；暴露8小时后所有包囊均被杀死。软性隐形眼镜护理液在孵育8小时后均未杀死任何一种菌株的10个包囊。
两种受试隐形眼镜护理液（用于硬性透气性隐形眼镜的护理液）可破坏所有菌株的包囊。其中一种含有两种杀阿米巴成分的组合，即使仅暴露一小时也有此效果。
