Hiti K, Walochnik J, Faschinger C, Haller-Schober E-M, Aspöck H
1Department of Ophthalmology, University of Graz, Austria.
Eye (Lond). 2005 Dec;19(12):1301-5. doi: 10.1038/sj.eye.6701752.
Effective contact lens disinfection solutions are important to keep the storage case free of acanthamoebae and thus prevent an infection of the eye. The aim of our study was to evaluate the effectivity of two new one-step hydrogen peroxide disinfecting solutions against Acanthamoeba spp. and compare it to the effectivity of other commercially available systems.
Nine one-step 3% hydrogen peroxide systems including the new systems Silver Sept (platinum and silver disk for intensifying disinfection) and Blue Vision (newly composed catalytic tablet) and 2 two-step systems (0.6 and 3.0% H(2)O(2)) were tested for their effectivity against cysts of two Acanthamoeba keratitis isolates at different concentrations.
After a soaking time of 8 h (overnight soaking of contact lenses) the 2 two-step systems completely destroyed the cysts of both Acanthamoeba strains, even at the highest concentration of cysts tested. The nine tested one-step systems showed weaker effects. The new Blue Vision system was able to eradicate the cysts of one strain at the low concentration of cysts.
One-step hydrogen peroxide systems do not have sufficient effects on Acanthamoeba cysts and therefore may not protect the contact lens user from a possible infection of the eye. Further development of tablets like the ones used in the Blue Vision system may result in better cysticidal effects for one-step systems.
有效的隐形眼镜消毒溶液对于保持储存盒无棘阿米巴原虫从而预防眼部感染至关重要。我们研究的目的是评估两种新型一步法过氧化氢消毒溶液对棘阿米巴属的有效性，并将其与其他市售系统的有效性进行比较。
测试了九种一步法3%过氧化氢系统，包括新型系统Silver Sept（用于强化消毒的铂和银盘）和Blue Vision（新配制的催化片剂）以及两种两步法系统（0.6%和3.0% H₂O₂）在不同浓度下对两种棘阿米巴角膜炎分离株囊肿的有效性。
浸泡8小时（隐形眼镜过夜浸泡）后，两种两步法系统即使在测试的最高囊肿浓度下也能完全破坏两种棘阿米巴菌株的囊肿。九个测试的一步法系统效果较弱。新型Blue Vision系统在低囊肿浓度下能够根除一种菌株的囊肿。
一步法过氧化氢系统对棘阿米巴囊肿的效果不足，因此可能无法保护隐形眼镜使用者免受眼部可能的感染。像Blue Vision系统中使用的片剂的进一步开发可能会使一步法系统产生更好的杀囊肿效果。
