儿茶酚-O-甲基转移酶基因Val158Met多态性与慢性肌肉骨骼疾病无关联。HUNT研究。
No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT study.
作者信息
Hagen Knut, Pettersen Elin, Stovner Lars Jacob, Skorpen Frank, Zwart John-Anker
机构信息
Department of Clinical Neuroscience; Norwegian University of Science and Technology, Trondheim, Norway.
出版信息
BMC Musculoskelet Disord. 2006 May 4;7:40. doi: 10.1186/1471-2474-7-40.
Abstract
BACKGROUND
The Catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, that has been found to influence human pain perception. In one study fibromyalgia was less likely among those with Val/Val genotype.
METHODS
In the 1995-97 Nord-Trøndelag Health Study (HUNT), the association between Val/Met polymorphism at the COMT gene and chronic musculoskeletal complaints (MSCs) was evaluated in a random sample of 3017 individuals.
RESULTS
The distribution of the COMT Val158Met genotypes and alleles were similar between controls and the twelve different chronic MSCs groups. Even when the Met/Met and Val/Met genotypes were pooled, the distribution of the Val/Val genotype and other genotypes were similar between controls and the chronic MSCs groups.
CONCLUSION
In this population-based study, no significant association was found between Val/Met polymorphism at the COMT gene and chronic MSCs.
摘要
背景
儿茶酚-O-甲基转移酶（COMT）基因包含一种功能性多态性，即Val158Met，已发现其会影响人类的疼痛感知。在一项研究中，Val/Val基因型的个体患纤维肌痛的可能性较小。
方法
在1995 - 1997年的北特伦德拉格健康研究（HUNT）中，对3017名个体的随机样本评估了COMT基因处Val/Met多态性与慢性肌肉骨骼疾病（MSCs）之间的关联。
结果
对照组与十二个不同的慢性MSCs组之间，COMT Val158Met基因型和等位基因的分布相似。即使将Met/Met和Val/Met基因型合并，对照组与慢性MSCs组之间Val/Val基因型和其他基因型的分布也相似。
结论
在这项基于人群的研究中，未发现COMT基因处Val/Met多态性与慢性MSCs之间存在显著关联。
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