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儿茶酚-O-甲基转移酶Val158Met基因多态性对普通人群生存的影响——HUNT研究

The impact of the catechol-O-methyltransferase Val158Met polymorphism on survival in the general population--the HUNT study.

作者信息

Hagen Knut, Stovner Lars J, Skorpen Frank, Pettersen Elin, Zwart John-Anker

机构信息

Department of Clinical Neuroscience, Faculty of medicine, Norwegian University of Science and Technology, Trondheim, Norway.

出版信息

BMC Med Genet. 2007 Jun 19;8:34. doi: 10.1186/1471-2350-8-34.

DOI:10.1186/1471-2350-8-34
PMID:17577421
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1906749/
Abstract

BACKGROUND

The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met which has been related to common diseases like cancer, psychiatric illness and myocardial infarction. Whether the Val158Met polymorphism is associated with survival has not been evaluated in the general population. The aim of this prospective study was to evaluate the impact of codon 158 COMT gene polymorphism on survival in a population-based cohort.

METHODS

The sample comprised 2979 non-diabetic individuals who participated in the Nord-Trøndelag Health Study (HUNT) in the period 1995-97. The subjects were followed up with respect to mortality throughout year 2004.

RESULTS

212 men and 183 women died during the follow up. No association between codon 158 COMT gene polymorphism and survival was found. The unadjusted relative risk of death by non-ischemic heart diseases with Met/Met or Met/Val genotypes was 3.27 (95% confidence interval, 1.19-9.00) compared to Val/Val genotype. When we adjusted for age, gender, smoking, coffee intake and body mass index the relative risk decreased to 2.89 (95% confidence interval, 1.04-8.00).

CONCLUSION

During 10 year of follow-up, the Val158Met polymorphism had no impact on survival in a general population. Difference in mortality rates from non-ischemic heart diseases may be incidental and should be evaluated in other studies.

摘要

背景

儿茶酚-O-甲基转移酶（COMT）基因包含一个功能性多态性位点Val158Met，该位点与癌症、精神疾病和心肌梗死等常见疾病有关。Val158Met多态性是否与生存率相关尚未在普通人群中进行评估。这项前瞻性研究的目的是评估COMT基因第158位密码子多态性对基于人群队列生存率的影响。

方法

样本包括1995 - 1997年期间参加北特伦德拉格健康研究（HUNT）的2979名非糖尿病个体。对这些受试者在2004年全年进行了死亡率随访。

结果

随访期间有212名男性和183名女性死亡。未发现COMT基因第158位密码子多态性与生存率之间存在关联。与Val/Val基因型相比，Met/Met或Met/Val基因型的非缺血性心脏病死亡的未调整相对风险为3.27（95%置信区间，1.19 - 9.00）。当我们对年龄、性别、吸烟、咖啡摄入量和体重指数进行调整后，相对风险降至2.89（95%置信区间，1.04 - 8.00）。

结论

在10年的随访期间，Val158Met多态性对普通人群的生存率没有影响。非缺血性心脏病死亡率的差异可能是偶然的，应在其他研究中进行评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e2/1906749/dde80fb71610/1471-2350-8-34-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e2/1906749/5e28fce3a780/1471-2350-8-34-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e2/1906749/dde80fb71610/1471-2350-8-34-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e2/1906749/5e28fce3a780/1471-2350-8-34-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e2/1906749/dde80fb71610/1471-2350-8-34-2.jpg

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