Marhl Marko, Grubelnik Vladimir
Department of Physics, University of Maribor, Koroska Cesta 160, SI-2000 Maribor, Slovenia.
Biosystems. 2007 Jan;87(1):58-67. doi: 10.1016/j.biosystems.2006.03.004. Epub 2006 May 3.
In biological signal transduction pathways intermediates are often oscillatory and need to be converted into smooth output signals at the end. We show by mathematical modelling that protein kinase cascades enable converting oscillatory signals into sharp stationary step-like outputs. The importance of this result is demonstrated for the switch-like protein activation by calcium oscillations, which is of biological importance for regulating different cellular processes. In addition, we found that protein kinase cascades cause memory effects in the protein activation, which might be of a physiological advantage since a smaller amount of calcium transported in the cell is required for an effective activation of cellular processes.
在生物信号转导途径中，中间体常常是振荡性的，最终需要被转换为平滑的输出信号。我们通过数学建模表明，蛋白激酶级联能够将振荡信号转换为尖锐的稳态阶跃样输出。这一结果的重要性在钙振荡引发的开关样蛋白激活中得到了证明，而这种激活对于调节不同细胞过程具有生物学重要性。此外，我们发现蛋白激酶级联在蛋白激活过程中会产生记忆效应，这可能具有生理优势，因为细胞内有效激活细胞过程所需运输的钙量较少。
