Marhl Marko, Perc Matjaz, Schuster Stefan
Department of Physics, Faculty of Education, University of Maribor, Slovenia.
FEBS Lett. 2005 Oct 24;579(25):5461-5. doi: 10.1016/j.febslet.2005.09.007. Epub 2005 Sep 27.
We show by mathematical modelling that a two-level protein cascade can act as a band-pass filter for time-limited oscillations. The band-pass filters are then combined into a network of three-level signalling cascades that by filtering the frequency of time-limited oscillations selectively switches cellular processes on and off. The physiological relevance for the selective regulation of cellular processes is demonstrated for the case of regulation by time-limited calcium oscillations.
