一种用于解码限时Ca2+振荡的最小模型。

A minimal model for decoding of time-limited Ca2+ oscillations.

作者信息

Marhl Marko, Perc Matjaz, Schuster Stefan

机构信息

Department of Physics, Faculty of Education, University of Maribor, Koroska cesta 160, SI-2000 Maribor, Slovenia.

出版信息

Biophys Chem. 2006 Apr 1;120(3):161-7. doi: 10.1016/j.bpc.2005.11.005. Epub 2005 Dec 9.

DOI:10.1016/j.bpc.2005.11.005

PMID:16338050

Abstract

Calcium oscillations regulate several cellular processes by activating particular proteins. Most theoretical studies focused on the idealized situation of infinitely long oscillations. Here we analyze information transfer by time-limited calcium spike trains. We show that proteins can be selectively activated in a resonance-like manner by time-limited spike trains of different frequencies, while infinitely long oscillations do not show this resonance phenomenon. We found that proteins are activated more specifically by shorter oscillatory signals with narrower spikes.

摘要

钙振荡通过激活特定蛋白质来调节多种细胞过程。大多数理论研究集中在无限长振荡的理想化情况。在此，我们分析限时钙尖峰序列的信息传递。我们表明，蛋白质可以被不同频率的限时尖峰序列以类似共振的方式选择性激活，而无限长振荡则不显示这种共振现象。我们发现，蛋白质被具有更窄尖峰的较短振荡信号更特异性地激活。