Schmitt J J, Janszky J, Woermann F, Tuxhorn I, Ebner A
Department of Presurgical Evaluation, Epilepsy Center Bethel, Maraweg 21, 33617 Bielefeld, Germany.
Epilepsy Behav. 2006 Jun;8(4):773-5. doi: 10.1016/j.yebeh.2006.03.003. Epub 2006 May 3.
We report the induction of laughter and smiling by cortical electrical stimulation of the frontal lobe of two patients: an 18-month-old boy with a left frontal cortical lesion extending to the vertex and the central gyrus, and a 35-year-old woman with a lesion in the right supplementary sensorimotor area (SSMA). The subjects underwent presurgical epilepsy evaluation with subdural grid electrodes to determine surgical candidacy. Stimulation of the prefrontal area reproducibly induced laughter. The adult patient reported absence of emotional content. Slowing of speech occurred under stimulation of electrodes in the upper and posterior vicinity. In this patient laughter was elicited in the anterior part of the SSMA. In the child, this response was induced by stimulation of the lateral prefrontal cortex near the midline. We conclude that the anterior portion of the SSMA/lateral premotor cortex is involved in generating the motor pattern of laughter.
一名18个月大的男孩，左侧额叶皮质病变延伸至头顶和中央回；一名35岁女性，右侧辅助感觉运动区（SSMA）有病变。受试者接受了术前癫痫评估，使用硬膜下格栅电极以确定手术候选资格。刺激前额叶区域可重复性地诱发笑声。成年患者报告没有情感内容。在电极刺激上方和后方附近区域时出现言语迟缓。在该成年患者中，SSMA前部诱发了笑声。在儿童中，这种反应是由刺激中线附近的外侧前额叶皮质引起的。我们得出结论，SSMA/外侧运动前皮层的前部参与了笑声运动模式的产生。
