Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
Epilepsia Open. 2023 Jun;8(2):547-558. doi: 10.1002/epi4.12729. Epub 2023 Apr 4.
The cortical representation of emotions is complex, and cortical mapping of emotional experience is incomplete. We aimed to contribute to cortical mapping of emotional experience.
Clinical data from 400 patients with medically refractory epilepsy who underwent stereo-electroencephalography implantation for localization of the epileptogenic zone at the Beijing Institute of Functional Neurosurgery between October 2015 and June 2021 were collected retrospectively. Furthermore, we reviewed studies that described cortical mapping of emotional experience through electrical cortical stimulation (ECS). Affective responses similar to ictal aura and electrode contacts located in the SOZ were excluded to investigate emotional experiences in normal brain regions.
Emotional experiences were evoked by stimulation at 10 electrode contacts in the seven patients, including five contacts that evoked mirth and excitement, one contact that evoked calmness, three contacts that evoked fear, and one contact that evoked sadness. In addition, 21 studies that evaluated emotional experiences in response to cortical electrical stimulation were reviewed. Emotions were distributed in the amygdala, hippocampus, temporal lobe, frontal lobe, insula, frontal operculum, parietal operculum, and cingulate cortex.
We provided additional evidence that brain regions including the amygdala, hippocampus, temporal lobe, frontal lobe, insula, frontal operculum, parietal operculum, and cingulate cortex were associated with emotional experience.
情绪的皮质代表复杂，情绪体验的皮质映射不完整。我们旨在为情绪体验的皮质映射做出贡献。
回顾性收集了 2015 年 10 月至 2021 年 6 月在北京功能神经外科研究所进行致痫灶定位的 400 例药物难治性癫痫患者的立体脑电图植入术的临床资料。此外，我们还回顾了描述通过电皮质刺激（ECS）进行情绪体验皮质映射的研究。排除与癫痫发作先兆和 SOZ 中电极接触相似的情感反应，以研究正常脑区的情感体验。
7 名患者中有 10 个电极接触点可诱发情绪体验，包括 5 个可诱发喜悦和兴奋的接触点、1 个可诱发平静的接触点、3 个可诱发恐惧的接触点和 1 个可诱发悲伤的接触点。此外，还回顾了 21 项评估皮质电刺激引起的情绪体验的研究。情绪分布在杏仁核、海马体、颞叶、额叶、脑岛、额骨盖、顶骨盖和扣带回皮质。
我们提供了额外的证据表明，包括杏仁核、海马体、颞叶、额叶、脑岛、额骨盖、顶骨盖和扣带回皮质在内的大脑区域与情绪体验有关。
