Morris Richard G M, Inglis Jennifer, Ainge James A, Olverman Henry J, Tulloch Jane, Dudai Yadin, Kelly Paul A T
Laboratories for Cognitive Neuroscience and Centre for Cognitive and Neural Systems, The University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, Scotland.
Neuron. 2006 May 4;50(3):479-89. doi: 10.1016/j.neuron.2006.04.012.
Reconsolidation is a putative neuronal process in which the retrieval of a previously consolidated memory returns it to a labile state that is once again subject to stabilization. This study explored the idea that reconsolidation occurs in spatial memory when animals retrieve memory under circumstances in which new memory encoding is likely to occur. Control studies confirmed that intrahippocampal infusions of anisomycin inhibited protein synthesis locally and that the spatial training protocols we used are subject to overnight protein synthesis-dependent consolidation. We then compared the impact of anisomycin in two conditions: when memory retrieval occurred in a reference memory task after performance had reached asymptote over several days; and after a comparable extent of training of a delayed matching-to-place task in which new memory encoding was required each day. Sensitivity to intrahippocampal anisomycin was observed only in the protocol involving new memory encoding at the time of retrieval.
重新巩固是一种假定的神经元过程，在这个过程中，对先前巩固的记忆进行提取会使其恢复到不稳定状态，再次易于被稳定下来。本研究探讨了这样一种观点，即当动物在可能发生新记忆编码的情况下提取记忆时，空间记忆中会发生重新巩固。对照研究证实，海马体内注射茴香霉素会局部抑制蛋白质合成，并且我们使用的空间训练方案依赖于过夜的蛋白质合成依赖性巩固。然后，我们比较了茴香霉素在两种情况下的影响：一种是在经过数天表现达到渐近线后，在参考记忆任务中进行记忆提取时；另一种是在每天都需要进行新记忆编码的延迟位置匹配任务经过相当程度的训练之后。仅在涉及提取时进行新记忆编码的方案中观察到对海马体内茴香霉素的敏感性。
