Osorio-Gómez Daniel, Miranda Maria Isabel, Guzmán-Ramos Kioko, Bermúdez-Rattoni Federico
División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Juriquilla, Mexico.
Front Syst Neurosci. 2023 Feb 21;17:1103770. doi: 10.3389/fnsys.2023.1103770. eCollection 2023.
Long-term memory is achieved through a consolidation process where structural and molecular changes integrate information into a stable memory. However, environmental conditions constantly change, and organisms must adapt their behavior by updating their memories, providing dynamic flexibility for adaptive responses. Consequently, novel stimulation/experiences can be integrated during memory retrieval; where consolidated memories are updated by a dynamic process after the appearance of a prediction error or by the exposure to new information, generating edited memories. This review will discuss the neurobiological systems involved in memory updating including recognition memory and emotional memories. In this regard, we will review the salient and emotional experiences that promote the gradual shifting from displeasure to pleasure (or vice versa), leading to hedonic or aversive responses, throughout memory updating. Finally, we will discuss evidence regarding memory updating and its potential clinical implication in drug addiction, phobias, and post-traumatic stress disorder.
长期记忆是通过一个巩固过程实现的，在这个过程中，结构和分子变化将信息整合到稳定的记忆中。然而，环境条件不断变化，生物体必须通过更新记忆来调整其行为，为适应性反应提供动态灵活性。因此，新的刺激/体验可以在记忆检索过程中被整合；在出现预测误差或接触新信息后，通过一个动态过程更新巩固的记忆，从而产生经过编辑的记忆。本综述将讨论参与记忆更新的神经生物学系统，包括识别记忆和情绪记忆。在这方面，我们将回顾在整个记忆更新过程中促进从不愉快到愉快（或反之亦然）逐渐转变的显著和情绪体验，从而导致享乐或厌恶反应。最后，我们将讨论有关记忆更新的证据及其在药物成瘾、恐惧症和创伤后应激障碍中的潜在临床意义。
