Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.
Int J Biochem Cell Biol. 2012 Jun;44(6):842-6. doi: 10.1016/j.biocel.2012.02.009. Epub 2012 Feb 21.
Calreticulin is an endoplasmic reticulum Ca(2+) binding chaperone that has multiple functions inside and outside of the endoplasmic reticulum. It is involved in the quality control of newly synthesized proteins and glycoproteins, interacting with various other endoplasmic reticulum chaperones, specifically calnexin and ER protein of 57-kDa in the calreticulin/calnexin cycle. Calreticulin also plays a crucial role in regulating intracellular Ca(2+) homeostasis, associating calreticulin with a wide variety of signaling processes, such as cardiogenesis, adipocyte differentiation and cellular stress responses. The role of calreticulin outside of the endoplasmic reticulum is also extensive, including functions in wound healing and immunity. Therefore, calreticulin has important implications in health and disease. Signaling facts.
钙网蛋白是内质网 Ca(2+)结合伴侣，在内质网内外具有多种功能。它参与新合成蛋白质和糖蛋白的质量控制，与各种其他内质网伴侣，特别是钙网蛋白/钙联蛋白循环中的 calnexin 和 57-kDa ER 蛋白相互作用。钙网蛋白在调节细胞内 Ca(2+)稳态中也起着至关重要的作用，钙网蛋白与各种信号过程相关联，如心脏发生、脂肪细胞分化和细胞应激反应。钙网蛋白在内质网外的作用也很广泛，包括在伤口愈合和免疫中的功能。因此，钙网蛋白在健康和疾病中具有重要意义。信号事实。
