Carballido-López Rut
Génétique Microbienne, Institut National de la Recherche Agronomique, 78352 Jouy-en-Josas cedex, France.
Mol Microbiol. 2006 May;60(4):815-9. doi: 10.1111/j.1365-2958.2006.05161.x.
MreB proteins are bacterial homologues of actin that directly determine cell shape and are involved in a range of other cellular processes in non-spherical bacteria. Like F-actin in eukaryotes, MreBs self-assemble into dynamic filamentous structures that are essential for cell viability. Recent studies have demonstrated that the MreB cytoskeletal scaffold governs shape determination by controlling functions related to the bacterial cell wall (probably by recruiting and directing peptidoglycan-synthesizing and modifying proteins). Here I consider general implications for bacterial morphogenesis, and the basis for differences in wall expansion and cylindrical cell shape, based on recent studies aimed to determine the role of MreBs in bacteria with different modes of growth.
MreB蛋白是肌动蛋白的细菌同源物，直接决定细胞形状，并参与非球形细菌的一系列其他细胞过程。与真核生物中的F-肌动蛋白一样，MreB自组装成动态丝状结构，这对细胞活力至关重要。最近的研究表明，MreB细胞骨架支架通过控制与细菌细胞壁相关的功能（可能是通过招募和指导肽聚糖合成及修饰蛋白）来决定形状。在此，我基于最近旨在确定MreB在不同生长模式细菌中的作用的研究，探讨其对细菌形态发生的一般影响，以及细胞壁扩张和圆柱形细胞形状差异的基础。
