McCutcheon N B
Department of Psychology, University at Albany, State University of New York 12222.
Behav Neurosci. 1991 Oct;105(5):764-6. doi: 10.1037//0735-7044.105.5.764.
Rats were made sodium deficient by furosemide injection and then offered 20 min of access to 0.05 M NaCl mixed with the sodium channel blocker amiloride. Compared with a sodium deficient control group that was also offered 0.05 M NaCl, these rats drank very little. A subsequent test conducted in the same manner with 20 min of access to 0.3 M NaCl mixed with amiloride produced similar results. It is concluded that amiloride blocks the neural information required for generating the attractive taste of NaCl to the sodium deficient rat.
通过注射速尿使大鼠缺钠，然后让它们有20分钟的时间接触与钠通道阻滞剂阿米洛利混合的0.05M氯化钠。与同样接触0.05M氯化钠的缺钠对照组相比，这些大鼠饮水量很少。随后以相同方式进行的一项测试，让大鼠有20分钟的时间接触与阿米洛利混合的0.3M氯化钠，也产生了类似的结果。得出的结论是，阿米洛利阻断了缺钠大鼠产生对氯化钠诱人味道的神经信息。
