Rabouille Catherine, Kondylis Vangelis
University Medical Center Utrecht, The Cell Microscopy Center, Department of Cell Biology and Institute of Biomembranes, Heidelberglaan 100, 3584CX Utrecht, The Netherlands.
Genome Biol. 2006;7(4):213. doi: 10.1186/gb-2006-7-4-213. Epub 2006 Apr 28.
Although the organization and functions of the constitutive secretory pathway have been intensively studied for decades, a recent genome-wide RNAi screen in Drosophila cells has identified about 100 genes encoding novel so-called TANGO proteins (for transport and Golgi organization) that may be direct regulators of various aspects of protein exocytosis or secretion.
尽管组成型分泌途径的组织和功能已被深入研究了数十年，但最近在果蝇细胞中进行的全基因组RNA干扰筛选已鉴定出约100个编码新型所谓TANGO蛋白（用于运输和高尔基体组织）的基因，这些基因可能是蛋白质胞吐作用或分泌各个方面的直接调节因子。
