Robertson Charles M, Coopersmith Craig M
Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8109, St. Louis, MO 63110, USA.
Microbes Infect. 2006 Apr;8(5):1382-9. doi: 10.1016/j.micinf.2005.12.016. Epub 2006 Mar 23.
The systemic inflammatory response syndrome (SIRS) is the body's response to an infectious or noninfectious insult. Although the definition of SIRS refers to it as an "inflammatory" response, it actually has pro- and anti-inflammatory components. This review outlines the pathophysiology of SIRS and highlights potential targets for future therapeutic intervention in patients with this complex entity.
全身炎症反应综合征(SIRS)是机体对感染性或非感染性损伤的反应。尽管SIRS的定义将其称为“炎症”反应,但它实际上具有促炎和抗炎成分。本综述概述了SIRS的病理生理学,并强调了针对这一复杂病症患者未来治疗干预的潜在靶点。