Secor V H
Crit Care Nurs Clin North Am. 1994 Jun;6(2):251-64.
The inflammatory/immune response is designed to protect the body and limit the extent of injury. In the setting of critical illness, however, regulation of this exquisite response is often lost for reasons that remain to be elucidated. Loss of regulation combined with shock, infection, inflammation, and/or ischemia often leads to the development of the systemic inflammatory response syndrome (SIRS), which frequently is associated with the development of septic shock, disseminated intravascular coagulation (DIC), multiple organ dysfunction (MODS), and other complications of critical illness.
炎症/免疫反应旨在保护身体并限制损伤程度。然而，在危重病情况下，这种精妙反应的调节常常丧失，原因尚待阐明。调节丧失加上休克、感染、炎症和/或缺血，常常导致全身炎症反应综合征（SIRS）的发生，而SIRS又常常与感染性休克、弥散性血管内凝血（DIC）、多器官功能障碍（MODS）以及其他危重病并发症的发生相关。
