Nakano Yasuyuki, Matsuo Saburo, Tani Hiroyuki, Sasai Kazumi, Baba Eiichiroh
Department of Veterinary Clinical Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Japan.
J Vet Med Sci. 2006 Apr;68(4):373-4. doi: 10.1292/jvms.68.373.
An eardrop solution of beta-thujaplicin was examined for therapeutic effects on canine Malassezia-related otitis externa. Half to one ml of beta-thujaplicin solution of 100 microg/ml including DMSO 2% was injected everyday into both external ear canals of 31 cases for test-of-cure agreement. Fifteen score phases were established from the symptoms and cerumen smear biopsy findings, and score changes were recorded at least once a week. The means of the second and the third inspection day scores decreased significantly more than the previous value of each. In addition, the numbers of yeast-like organisms clearly decreased. These results suggest that beta-thujaplicin eardrops are effective for Malassezia-related otitis externa in dogs.
对β-崖柏素耳滴剂治疗犬马拉色菌相关性外耳炎的疗效进行了研究。将100微克/毫升含2%二甲基亚砜的β-崖柏素溶液0.5至1毫升每天注入31例犬的双侧外耳道，以进行治愈性验证试验。根据症状和耳垢涂片活检结果确定了15个评分阶段，每周至少记录一次评分变化。第二次和第三次检查日的平均评分比各自之前的值显著降低。此外，酵母样生物体的数量明显减少。这些结果表明，β-崖柏素耳滴剂对犬马拉色菌相关性外耳炎有效。
