Ueno Kiyonobu, Kusunoki Yoko, Imamura Fumio, Yoshimura Mana, Yamamoto Suguru, Uchida Junji, Tsukamoto Yoshitane
Department of Pulmonary Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
Respiration. 2007;74(3):304-8. doi: 10.1159/000093233. Epub 2006 May 5.
It is important to detect preinvasive bronchial lesions before they become invasive cancer, because detection of early cancer is expected to lead to a cure. Autofluorescence bronchoscopy is a useful device in the detection of preinvasive and cancerous lesions. Recently, a new autofluorescence bronchoscopic system, autofluorescence imaging (AFI) system, has been developed.
We evaluated the efficacy of AFI in the diagnosis of precancerous and cancerous lesions.
A total of 31 patients underwent both conventional white-light bronchoscopy (WLB) and AFI from January 2002 to September 2004. We evaluated autofluorescence findings using a four-point scale: AFI-I, II, III, and B. The findings in WLB were evaluated on a three-point scale: WLB-I, II, and III. Abnormal areas by WLB and AFI were biopsied for histopathological examinations.
A total of 64 lesions were evaluated. When the AFI-III finding was regarded as positive in AFI and WLB-III as positive in WLB, sensitivity for severe dysplasia or worse was 94.7% with AFI and 73.7% with WLB, respectively.
AFI is an effective system for the detection of precancerous and cancerous lesions.
在浸润性癌形成之前检测支气管原位病变很重要，因为早期癌症的检测有望实现治愈。自体荧光支气管镜检查是检测原位病变和癌性病变的一种有用设备。最近，一种新的自体荧光支气管镜系统，即自体荧光成像（AFI）系统已被开发出来。
我们评估了AFI在癌前病变和癌性病变诊断中的有效性。
2002年1月至2004年9月，共有31例患者接受了传统白光支气管镜检查（WLB）和AFI检查。我们使用四点量表评估自体荧光检查结果：AFI-I、II、III和B。WLB的检查结果使用三点量表进行评估：WLB-I、II和III。对WLB和AFI显示的异常区域进行活检以进行组织病理学检查。
共评估了64个病变。当AFI中的AFI-III结果被视为阳性且WLB中的WLB-III被视为阳性时，AFI对重度发育异常或更严重病变的敏感性为94.7%，WLB为73.7%。
AFI是检测癌前病变和癌性病变的有效系统。
