Tsakas Sotiris, Goumenos Dimitrios S
Laboratory of Biology, Department of Biology, University of Patras, Patras, Greece.
Am J Nephrol. 2006;26(2):186-93. doi: 10.1159/000093178. Epub 2006 May 4.
Transforming growth factorbeta1 (TGF-beta1) is the main modulator of the healing process after tissue injury. In the kidney, if TGF-beta1 release is not switched off, extracellular matrix components (ECM) are accumulated and tissue fibrosis occurs. Urinary TGF-beta1 levels reflect its renal production and it has been determined in various types of glomerular disease. In this review, a critical analysis of the different immunoassays that have been used for the measurement of TGF-beta1 in the urine is presented and the importance of the serial determination of urinary TGF-beta1 levels in patients with various types of renal disease is discussed.
转化生长因子β1（TGF-β1）是组织损伤后愈合过程的主要调节因子。在肾脏中，如果TGF-β1的释放不被关闭，细胞外基质成分（ECM）就会积累，进而发生组织纤维化。尿TGF-β1水平反映其在肾脏中的产生情况，并且已经在各种类型的肾小球疾病中得到测定。在本综述中，对已用于测量尿液中TGF-β1的不同免疫测定方法进行了批判性分析，并讨论了在各类肾病患者中连续测定尿TGF-β1水平的重要性。
