Rojas Vega Sandra, Strüder Heiko K, Wahrmann Bertha Vera, Bloch Wilhelm, Hollmann Wildor
Institute of Motor Control and Movement Technique, German Sport University Cologne, Cologne, Germany.
Med Sci Sports Exerc. 2006 Apr;38(4):675-80. doi: 10.1249/01.mss.0000210195.94952.50.
The aim of the study was to examine the effect of acid-base status on serum prolactin (PRL) concentration postexercise.
Seven male recreational athletes participated in two experimental trials separated by 1 wk. In the respective trial, subjects received either a placebo infusion (normal isotonic saline) or an alkali infusion (isotonic sodium bicarbonate) before and during exercise. Venous and capillary blood samples were drawn at rest, immediately after a 10-min warm-up period, and after a maximal ramp test on a cycle ergometer, as well as at 3, 6, 10, and 15 min postexercise.
Power output, HR, capillary blood lactate concentration, carbon dioxide pressure (PCO2), and partial oxygen pressure (PO2) did not differ between trials at any point in time. Capillary PO2 did not change from resting values, but a significant increase (P < 0.05) was found from the end of warm-up to 3 min of the recovery period. Exercise induced a significant (P < 0.01) decrease in capillary blood bicarbonate concentration (HCO3-), pH, base excess (BE), and PCO2 at exhaustion and during the recovery period. Significantly higher HCO3-, pH, and BE were found during bicarbonate infusion and postexercise in comparison with the placebo trial. Serum PRL concentration was significantly increased 3 min postexercise until the end of the placebo trial, whereas after bicarbonate infusion, serum PRL concentration did not change from values at rest. Significant (P < 0.01) differences between trials in serum PRL concentration were found 10 and 15 min postexercise.
The present study suggests that acidosis is a stimulus for exercise-induced PRL secretion.
本研究旨在探讨酸碱状态对运动后血清催乳素（PRL）浓度的影响。
七名男性休闲运动员参加了两项实验性试验，间隔1周。在各自的试验中，受试者在运动前和运动期间接受安慰剂输注（等渗生理盐水）或碱输注（等渗碳酸氢钠）。在静息状态、10分钟热身期结束后、在自行车测力计上进行最大递增负荷试验后以及运动后3、6、10和15分钟采集静脉血和毛细血管血样本。
在任何时间点，试验之间的功率输出、心率、毛细血管血乳酸浓度、二氧化碳分压（PCO2）和氧分压（PO2）均无差异。毛细血管PO2与静息值相比没有变化，但从热身结束到恢复期3分钟时发现有显著增加（P<0.05）。运动导致力竭时和恢复期毛细血管血碳酸氢盐浓度（HCO3-）、pH值、碱剩余（BE）和PCO2显著降低（P<0.01）。与安慰剂试验相比，碳酸氢盐输注期间和运动后发现HCO3-、pH值和BE显著更高。运动后3分钟直至安慰剂试验结束时血清PRL浓度显著升高，而在碳酸氢盐输注后，血清PRL浓度与静息值相比没有变化。运动后10分钟和15分钟时，试验之间血清PRL浓度存在显著（P<0.01）差异。
本研究表明酸中毒是运动诱导PRL分泌的刺激因素。
