Institute of Training Science and Sport Informatics, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933 Cologne, Germany.
Eur J Appl Physiol. 2011 Jul;111(7):1405-13. doi: 10.1007/s00421-010-1767-1. Epub 2010 Dec 15.
The purpose of the present study was to compare the acute hormonal response to a short-term high-intensity training (HIT) versus a high-volume endurance training (HVT) and to investigate the effects of acid-base status on cytokines involved in angiogenesis (VEGF and bFGF). Eleven subjects participated in three experimental trials. Two times subjects performed four 30-s "all-out" exercise bouts on a cycle ergometer separated by 5-min rest each, at which subjects either received bicarbonate (HIT (B)) or a placebo (HIT (P)) before the exercise. The third exercise trail consisted of a constant load exercise for 1 h at 50% peak power output (PPO). Venous blood samples were taken under resting conditions, 10, 60, and 240 min after each exercise condition to determine VEGF and bFGF serum concentrations. Capillary blood samples were taken to determine lactate concentrations and blood gas parameters. Mean pH values were significantly higher during HIT (B) compared to HIT (P). Serum VEGF concentration was significantly increased 10-min post-exercise in both HIT interventions. HVT showed no significant effects on VEGF levels. The diminished acidosis during HIT (B) had no effects on the VEGF response. There were no significant changes in bFGF in response to HIT or HVT. The present study suggests that HIT is a stimulus for exercise-induced VEGF secretion. These findings might be relevant for the arrangement of training, due to the fact that most of the training is often performed at low intensities possibly leading to an insufficient stimulus for VEGF secretion and angiogenesis.
本研究旨在比较短期高强度训练（HIT）与高容量耐力训练（HVT）对急性激素反应的影响，并探讨酸碱状态对参与血管生成的细胞因子（VEGF 和 bFGF）的影响。11 名受试者参加了三项实验。两次，受试者在自行车测力计上进行了四次 30 秒的“全力以赴”运动，每次运动之间休息 5 分钟，其中 HIT（B）组在运动前接受碳酸氢盐，而 HIT（P）组接受安慰剂。第三次运动试验包括以 50%峰值功率输出（PPO）持续负荷运动 1 小时。在休息状态、每种运动条件后 10、60 和 240 分钟时采集静脉血样，以确定 VEGF 和 bFGF 血清浓度。采集毛细血管血样以确定乳酸浓度和血气参数。与 HIT（P）相比，HIT（B）期间的平均 pH 值显著升高。两种 HIT 干预后，运动后 10 分钟 VEGF 浓度均显著升高。HVT 对 VEGF 水平没有显著影响。HIT（B）期间酸中毒减轻对 VEGF 反应没有影响。HIT 或 HVT 对 bFGF 没有显著变化。本研究表明，HIT 是运动引起的 VEGF 分泌的刺激因素。由于大多数训练通常在低强度下进行，可能导致 VEGF 分泌和血管生成的刺激不足，因此这些发现可能与训练安排有关。
