通过使用包含有机溶剂和离子液体的混合体系显著增强脂肪酶催化的核苷药物酯的合成。
Markedly enhancing lipase-catalyzed synthesis of nucleoside drugs' ester by using a mixture system containing organic solvents and ionic liquid.
作者信息
Liu Bo Kai, Wang Na, Chen Zhi Chun, Wu Qi, Lin Xian Fu
机构信息
Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China.
出版信息
Bioorg Med Chem Lett. 2006 Jul 15;16(14):3769-71. doi: 10.1016/j.bmcl.2006.04.054. Epub 2006 May 8.
PMID:16682199
Abstract
Eightfold higher yields and three times faster reaction rates were achieved by means of using a mixture solvent system composed of 90% acetone and 10% [BMIM]BF4 in the lipase-catalyzed regioselective synthesis of polymerizable ester of nucleoside drugs.
摘要
在脂肪酶催化的核苷药物可聚合酯的区域选择性合成中，通过使用由90%丙酮和10%[BMIM]BF4组成的混合溶剂体系，实现了高出八倍的产率和快三倍的反应速率。
相似文献
1
Markedly enhancing lipase-catalyzed synthesis of nucleoside drugs' ester by using a mixture system containing organic solvents and ionic liquid.通过使用包含有机溶剂和离子液体的混合体系显著增强脂肪酶催化的核苷药物酯的合成。
Bioorg Med Chem Lett. 2006 Jul 15;16(14):3769-71. doi: 10.1016/j.bmcl.2006.04.054. Epub 2006 May 8.
2
Controllable synthesis of polymerizable ester and amide prodrugs of acyclovir by enzyme in organic solvent.在有机溶剂中通过酶可控合成阿昔洛韦的可聚合酯和酰胺前药。
Bioorg Med Chem. 2006 May 15;14(10):3377-82. doi: 10.1016/j.bmc.2005.12.050. Epub 2006 Jan 20.
3
Lipase-catalyzed synthesis of fatty acid sugar ester using extremely supersaturated sugar solution in ionic liquids.在离子液体中使用极度过饱和糖溶液通过脂肪酶催化合成脂肪酸糖酯。
Biotechnol Bioeng. 2008 Jan 1;99(1):1-8. doi: 10.1002/bit.21534.
4
Facile synthesis of novel mutual derivatives of nucleosides and pyrimidines by regioselectively chemo-enzymatic protocol.通过区域选择性化学酶促方法简便合成新型核苷和嘧啶互变异构体衍生物。
Bioorg Med Chem. 2008 May 1;16(9):5181-8. doi: 10.1016/j.bmc.2008.03.012. Epub 2008 Mar 6.
5
Esterification activity and conformation studies of Burkholderia cepacia lipase in conventional organic solvents, ionic liquids and their co-solvent mixture media.在常规有机溶剂、离子液体及其共溶剂混合介质中，洋葱伯克霍尔德氏菌脂肪酶的酯化活性和构象研究。
Bioresour Technol. 2010 Dec;101(24):9822-4. doi: 10.1016/j.biortech.2010.07.107. Epub 2010 Aug 1.
6
Controllable regioselective enzymatic synthesis of polymerizable 5'-O-vinyl- and 3'-O-vinyl-nucleoside analogues in acetone.在丙酮中可控区域选择性酶促合成可聚合的5'-O-乙烯基和3'-O-乙烯基核苷类似物。
Biotechnol Lett. 2004 Jun;26(12):1019-22. doi: 10.1023/b:bile.0000030050.20353.a6.
7
Computer-aided real-time estimation of reaction conversion for lipase-catalyzed esterification in solvent-free systems.无溶剂体系中脂肪酶催化酯化反应转化率的计算机辅助实时估算
Biotechnol Bioeng. 2002 Sep 30;79(7):795-803. doi: 10.1002/bit.10339.
8
Competitive lipase-catalyzed ester hydrolysis and ammoniolysis in organic solvents; equilibrium model of a solid-liquid-vapor system.
Biotechnol Bioeng. 1999 Nov 5;65(3):347-56.
9
Optimization of lipase-catalyzed glucose ester synthesis in ionic liquids.离子液体中脂肪酶催化葡萄糖酯合成的优化。
Bioprocess Biosyst Eng. 2010 Jan;33(1):63-70. doi: 10.1007/s00449-009-0363-4. Epub 2009 Aug 13.
10
Enzymatic catalysis of formation of Z-aspartame in ionic liquid - An alternative to enzymatic catalysis in organic solvents.离子液体中酶催化合成Z-阿斯巴甜——有机溶剂中酶催化的替代方法
Biotechnol Prog. 2000 Nov-Dec;16(6):1129-31. doi: 10.1021/bp000094g.
引用本文的文献
1
The Role of Ionic Liquids in the Pharmaceutical Field: An Overview of Relevant Applications.离子液体在制药领域的作用：相关应用概述。
Int J Mol Sci. 2020 Nov 5;21(21):8298. doi: 10.3390/ijms21218298.
Zotero 插件