Aydogan K, Karadogan S K, Tunali S, Adim S B, Ozcelik T
Department of Dermatology, Uludag University Faculty of Medicine, Bursa, Turkey.
J Eur Acad Dermatol Venereol. 2006 May;20(5):573-7. doi: 10.1111/j.1468-3083.2006.01567.x.
Narrowband UVB (NB-UVB) phototherapy has been shown to be effective for the treatment of various dermatoses.
To analyze the effects of NB-UVB phototherapy for small plaque parapsoriasis (SPP).
The response of 45 patients (24 females, 21 males, age range 20-58 years) with histologically confirmed SPP were assessed. NB-UVB therapy was given 3-4 times weekly. The initial treatment dose was 70% of the minimal erythema dose. The doses were increased gradually with a standard increment of 20/10/0. Clinical response was determined as follows: complete response (CR), at least 90% clearing of skin lesions; partial response (PR), at least 50% but less than 90% clearing and no response (NR), less than 50% clearing. The follow-up period was 6-24 months after the treatment.
NB-UVB treatment led to CR in 33 of 45 patients (73.3%) with a mean cumulative dose of 14.3 J/cm(2) (range 3.2-24.1 J/cm(2)) after a mean number of 29 exposures (range 16-51 sessions); PR in 12 of 45 (26.6%) with a cumulative dose of 15.6 J/cm(2) (range 10.4-23.3 J/cm(2)) after a mean number of 29.4 exposures (range 25-50 sessions). Nineteen patients with CR had skin phototype II, 13 had type III and 1 had type I. Among the patients with PR, 7 had skin phototype II and 5 had type III. Postinflammatory hyperpigmentation was observed in 51% of the patients. Relapses occurred in six patients within a mean time of 7.5 months (2-12 months).
NB-UVB phototherapy has several advantages over treatment with broadband UVB and PUVA. NB-UVB therapy for patients with SPP is an effective, safe and practical alternative treatment modality. Further larger studies with longer follow-up periods are necessary to determine the proper clinical response and long-term complications of NB-UVB therapy in this disease.
窄谱中波紫外线（NB - UVB）光疗已被证明对多种皮肤病的治疗有效。
分析NB - UVB光疗对小斑块状副银屑病（SPP）的疗效。
评估45例经组织学确诊为SPP的患者（24例女性，21例男性，年龄范围20 - 58岁）的反应。NB - UVB治疗每周进行3 - 4次。初始治疗剂量为最小红斑量的70%。剂量以20/10/0的标准增量逐渐增加。临床反应判定如下：完全缓解（CR），皮肤病变至少90%消退；部分缓解（PR），至少50%但少于90%消退；无反应（NR），少于50%消退。治疗后随访6 - 24个月。
45例患者中，33例（73.3%）达到CR，平均累积剂量为14.3 J/cm²（范围3.2 - 24.1 J/cm²），平均照射次数为29次（范围16 - 51次）；45例中有12例（26.6%）达到PR，累积剂量为15.6 J/cm²（范围10.4 - 23.3 J/cm²），平均照射次数为29.4次（范围25 - 50次）。19例CR患者皮肤光型为Ⅱ型，13例为Ⅲ型，1例为Ⅰ型。PR患者中，7例皮肤光型为Ⅱ型，5例为Ⅲ型。51%的患者出现炎症后色素沉着。6例患者复发，平均复发时间为7.5个月（2 - 12个月）。
NB - UVB光疗相较于宽谱UVB和补骨脂素加长波紫外线（PUVA）治疗有多个优势。NB - UVB光疗对于SPP患者是一种有效、安全且实用的替代治疗方式。需要进一步开展更大规模、随访期更长的研究，以确定NB - UVB光疗在该疾病中的恰当临床反应和长期并发症。
