Department of Dermatology, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Rd., Jing'an District, Shanghai, China.
Department of Dermatology, Huadong Hospital, Fudan University, 221 West Yan-an Rd., Jing'an District, Shanghai, China.
Sci Rep. 2018 May 23;8(1):8051. doi: 10.1038/s41598-018-26388-3.
Psoriasis and parapsoriasis en plaques are chronic inflammatory skin diseases, both representing therapeutic challenge in daily practice and adversely affecting the quality of life. Reactive oxygen species (ROS) has been evidenced to be involved in the pathogenesis of the chronic inflammatory diseases. We now report that hydrogen water, an effective ROS scavenger, has significant and rapid improvement in disease severity and quality of life for patients with psoriasis and parapsoriasis en plaques. At week 8, our parallel-controlled trial revealed 24.4% of patients (10/41) receiving hydrogen-water bathing achieved at least 75% improvement in Psoriasis Area Severity Index (PASI) score compared with 2.9% of patients (1/34) of the control group (Pc = 0.022, OR = 0.094, 95%CI = [0.011, 0.777]). Of patients, 56.1% (23/41) who received bathing achieved at least 50% improvement in PASI score compared with only 17.7%(6/34) of the control group (P = 0.001, OR = 0.168, 95%CI = [0.057, 0.492]). The significant improvement of pruritus was also observed (P = 3.94 × 10). Besides, complete response was observed in 33.3% of patients (2/6) of parapsoriasis en plaques and partial response in 66.7% (4/6) at week 8. Our findings suggested that hydrogen-water bathing therapy could fulfill the unmet need for these chronic inflammatory skin diseases.
银屑病和斑块状副银屑病是慢性炎症性皮肤病，在日常实践中均具有治疗挑战性，并对生活质量产生不利影响。已证实活性氧（ROS）参与慢性炎症性疾病的发病机制。我们现在报告说，氢气水是一种有效的 ROS 清除剂，可显著快速改善银屑病和斑块状副银屑病患者的疾病严重程度和生活质量。在第 8 周，我们的平行对照试验显示，接受氢气水沐浴的患者中有 24.4%（10/41）的患者银屑病面积严重程度指数（PASI）评分至少改善了 75%，而对照组的患者只有 2.9%（1/34）（Pc=0.022，OR=0.094，95%CI=[0.011，0.777]）。接受沐浴治疗的患者中有 56.1%（23/41）的患者 PASI 评分至少改善了 50%，而对照组的患者只有 17.7%（6/34）（P=0.001，OR=0.168，95%CI=[0.057，0.492]）。瘙痒也有明显改善（P=3.94×10）。此外，在第 8 周，6 例斑块状副银屑病患者中，33.3%（2/6）的患者完全缓解，66.7%（4/6）的患者部分缓解。我们的研究结果表明，氢气水沐浴疗法可以满足这些慢性炎症性皮肤病的未满足需求。
