Aydogan Kenan, Saricaoglu Hayriye, Turan Hakan
Department of Dermatology, Faculty of Medicine, Uludag University, Bursa, Turkey.
Photodermatol Photoimmunol Photomed. 2008 Jun;24(3):128-33. doi: 10.1111/j.1600-0781.2008.00350.x.
BACKGROUND/PURPOSE: Narrowband (NB) UVB (NB-UVB) phototherapy has recently demonstrated high levels of efficacy and tolerability in a variety of skin diseases. The purpose of the present study was to assess the efficacy of NB-UVB phototherapy in the management of pityriasis lichenoides (PL).
The therapeutic response in 31 PL patients (23 pityriasis lichenoides et varioliformis acuta; PLEVA, eight pityriasis lichenoides chronica; PLC) treated with NB-UVB phototherapy between 2000 and 2007 was assessed.
NB-UVB treatment led to a complete response (CR) in 15 out of 23 PLEVA patients (65.2%) with a mean cumulative dose of 23 J/cm(2) after a mean number of 43.4 exposures and a partial response (PR) in eight patients (34.8%) with a cumulative dose of 15.6 J/cm(2) after a mean number of 32.3 exposures. NB-UVB treatment led to CR in seven out of eight PLC patients (87.5%) with a mean cumulative dose of 18.4 J/cm(2) after a mean number of 45.8 exposures and PR in one patient (12.5%) with a cumulative dose of 9.1 J/cm(2) after a mean number of 19 exposures. Relapses occurred in four PL patients within a mean time period of 6 months.
NB-UVB therapy is an effective, safe and practical alternative treatment modality for the management of PLEVA and PLC.
背景/目的：窄谱（NB）中波紫外线（NB-UVB）光疗最近已在多种皮肤病中显示出高度的疗效和耐受性。本研究的目的是评估NB-UVB光疗在治疗点滴状类银屑病（PL）中的疗效。
评估了2000年至2007年间接受NB-UVB光疗的31例PL患者（23例急性点滴状类银屑病；PLEVA，8例慢性点滴状类银屑病；PLC）的治疗反应。
NB-UVB治疗使23例PLEVA患者中的15例（65.2%）完全缓解（CR），平均累积剂量为23 J/cm²，平均照射次数为43.4次；8例患者（34.8%）部分缓解（PR），累积剂量为15.6 J/cm²，平均照射次数为32.3次。NB-UVB治疗使8例PLC患者中的7例（87.5%）完全缓解，平均累积剂量为18.4 J/cm²，平均照射次数为45.8次；1例患者（12.5%）部分缓解，累积剂量为9.1 J/cm²，平均照射次数为19次。4例PL患者在平均6个月的时间内复发。
NB-UVB疗法是治疗PLEVA和PLC的一种有效、安全且实用的替代治疗方式。
