Yang Xiaoming, Atalar Ergin
Department of Radiology, Johns Hopkins University, USA.
FEBS Lett. 2006 May 22;580(12):2958-61. doi: 10.1016/j.febslet.2006.04.027. Epub 2006 Apr 19.
MRI has the ability to generate high-contrast and high-resolution images, to obtain multiple diagnostic evaluations of organ function and morphology, and to provide multiple image planes with no risk of ionizing radiation. Recent efforts have focused on using MR technology to monitor gene delivery, to enhance gene transfection/transduction, and to track gene expression. This review summarizes the current status of MRI-guided gene therapy.
磁共振成像（MRI）能够生成高对比度和高分辨率的图像，对器官功能和形态进行多种诊断评估，并提供多个图像平面，且不存在电离辐射风险。近期的研究致力于利用磁共振技术监测基因传递、增强基因转染/转导以及追踪基因表达。本综述总结了MRI引导下基因治疗的现状。
