Amin Janaki, Dore Gregory J, O'Connell Dianne L, Bartlett Mark, Tracey Elizabeth, Kaldor John M, Law Matthew G
National Centre in HIV Epidemiology and Clinical Research, Sydney, Australia.
J Hepatol. 2006 Aug;45(2):197-203. doi: 10.1016/j.jhep.2006.02.014. Epub 2006 Mar 31.
BACKGROUND/AIMS: Risks of hepatocellular carcinoma (HCC) following hepatitis B and/or hepatitis C virus (HBV/HCV) infection are well known, those for other cancers are less well understood. The aim was to quantify the risk of cancers among persons diagnosed with HBV/HCV infections.
The data from a cohort of 39109 HBV, 75834 HCV, and 2604 HBV/HCV co-infected persons notified to the State health department, 1990-2002, were probabilistically linked to the Cancer Registry and standardised incidence ratios (SIRs) for cancer were calculated.
The match rate for any cancer was 2.7%, 2.3% and 3.3% for HBV, HCV and HBV/HCV co-infected notifications. SIRs for HCC were 30.6 (95% CI 25.7-36.5), 22.7 (95% CI 19.1-26.5) and 30.3 (95% CI 13.6-67.5), respectively. Increased risk was detected for Burkitt's lymphoma and HBV (SIR 12.9, 95% CI 5.4-30.9) and immunoproliferative malignancies following HCV (SIR 5.6, 95% CI 1.8-17.5).
The risk of HCC in the infected cohort was 20-30 times greater than in the uninfected population with SIRs two to three times greater than those for the other HBV/HCV infection associated cancers. The modest though significant risk of immunoproliferative malignancies associated with HCV infection is consistent with recent findings.
背景/目的：乙型肝炎和/或丙型肝炎病毒（HBV/HCV）感染后发生肝细胞癌（HCC）的风险已为人熟知，而对于其他癌症的风险则了解较少。目的是量化被诊断为HBV/HCV感染的人群患癌症的风险。
1990 - 2002年向州卫生部门报告的39109例HBV感染者、75834例HCV感染者和2604例HBV/HCV合并感染者的数据与癌症登记处进行概率关联，并计算癌症的标准化发病率（SIR）。
HBV、HCV和HBV/HCV合并感染报告的任何癌症匹配率分别为2.7%、2.3%和3.3%。HCC的SIR分别为30.6（95%可信区间25.7 - 36.5）、22.7（95%可信区间19.1 - 26.5）和30.3（95%可信区间13.6 - 67.5）。发现Burkitt淋巴瘤与HBV感染风险增加相关（SIR 12.9，95%可信区间5.4 - 30.9），免疫增殖性恶性肿瘤与HCV感染风险增加相关（SIR 5.6，95%可信区间1.8 - 17.5）。
感染队列中HCC的风险比未感染人群高20 - 30倍，SIR比其他HBV/HCV感染相关癌症高2 - 3倍。与HCV感染相关的免疫增殖性恶性肿瘤风险虽小但显著，这与近期研究结果一致。
