Fitzgerald Paul B, Benitez Jessica, Daskalakis Jeff Z, De Castella Anthony, Kulkarni Jayashri
Alfred Psychiatry Research Centre, The Alfred and Monash University Department of Psychological Medicine, Victoria, Australia.
World J Biol Psychiatry. 2006;7(2):119-22. doi: 10.1080/15622970500474705.
Auditory hallucinations are a common and disabling problem for many patients with schizophrenia and often fail to respond to optimal antipsychotic therapy. Repetitive transcranial magnetic stimulation (rTMS) has recently been trialled as an alternative treatment option for these patients. These studies have generally been positive, but treatment has only been provided for short periods of time and little is known about the longer-term impact of TMS on the course of hallucinations.
We describe two cases in which rTMS was provided to patients upon relapse of hallucinations following initial successful rTMS treatment in a clinical trial.
A repeat course of rTMS resulted in a marked improvement in the symptoms experienced by these two patients.
rTMS appears to have potential as a long-term treatment for patients with auditory hallucinations, but requires ongoing systematic investigation.
幻听是许多精神分裂症患者常见且致残的问题，通常对最佳抗精神病治疗无反应。重复经颅磁刺激（rTMS）最近已被试验作为这些患者的替代治疗选择。这些研究总体上是积极的，但治疗仅进行了短时间，关于TMS对幻觉病程的长期影响知之甚少。
我们描述了两例在临床试验中最初成功接受rTMS治疗后幻觉复发时接受rTMS治疗的患者。
rTMS的重复疗程使这两名患者的症状有显著改善。
rTMS似乎有作为幻听患者长期治疗的潜力，但需要持续的系统研究。
