Herr Thorsten, Kleger Paula, Strauss Sebastian, Szeska Christoph, Khalil Nura, Badran Bashar W, Weymar Mathias, Grothe Matthias
Department of Neurology, University Medicine Greifswald, Greifswald, Germany.
Department of Biological Psychology and Affective Science, Faculty of Human Sciences, University of Potsdam, Potsdam, Germany.
Front Neurol. 2024 Jan 12;14:1341898. doi: 10.3389/fneur.2023.1341898. eCollection 2023.
Transcutaneous auricular vagus nerve stimulation (taVNS) is becoming increasingly established in the treatment of various neurological and psychiatric diseases. However, only a few studies have focused on the overall influence of taVNS on cortical excitability in general. The planned study will investigate the effect of taVNS on the excitability of the motor cortex in young healthy subjects. The aim of the study is to gain better understand of the physiological mechanism of taVNS to contribute to new fields of application of taVNS in new areas such as the treatment of stroke or multiple sclerosis. This protocol describes a single-center, prospective, double blind, sham-controlled trial that evaluates the effect of taVNS on motor cortex excitability with a planned sample size of 30 participants. The effect of taVNS is investigated by neuronavigation and electromyography (EMG) coupled transcranial magnetic stimulation (TMS) applied before and after taVNS stimulation. The following parameters are assessed: resting motor threshold (RMT), active motor threshold (AMT), recruitment curve (RC), short intracortical inhibition (SICI), intracortical facilitation (ICF). All parameters will be assessed for taVNS on the basis of perception threshold and tolerance threshold. All investigations performed in the study were reviewed and approved by the local ethics committee of the University Medical Center Greifswald (study reference number: BB048/22).
www.drks.de, number: DRKS00029937.
经皮耳迷走神经刺激（taVNS）在各种神经和精神疾病的治疗中越来越得到认可。然而，总体而言，只有少数研究关注taVNS对皮质兴奋性的整体影响。本计划开展的研究将调查taVNS对年轻健康受试者运动皮质兴奋性的影响。该研究的目的是更好地理解taVNS的生理机制，为taVNS在中风或多发性硬化症治疗等新领域的应用做出贡献。本方案描述了一项单中心、前瞻性、双盲、假对照试验，该试验以30名参与者为计划样本量，评估taVNS对运动皮质兴奋性的影响。通过在taVNS刺激前后应用神经导航和肌电图（EMG）联合经颅磁刺激（TMS）来研究taVNS的效果。评估以下参数：静息运动阈值（RMT）、主动运动阈值（AMT）、募集曲线（RC）、短皮质内抑制（SICI）、皮质内易化（ICF）。将根据感知阈值和耐受阈值对taVNS的所有参数进行评估。本研究中进行的所有调查均经过格赖夫斯瓦尔德大学医学中心当地伦理委员会的审查和批准（研究参考编号：BB048/22）。
