Klemke Claus-Detlev, Goerdt Sergij, Schrama David, Becker Jürgen C
Department of Dermatology,Venereologie und Allergology,University Medical Center Mannheim, Ruprecht-Karls University Heidelberg, Mannheim, Germany.
J Dtsch Dermatol Ges. 2006 May;4(5):395-406. doi: 10.1111/j.1610-0387.2006.05982.x.
Cutaneous T-cell lymphoma is an extra-nodal non-Hodgkin lymphoma of mature T cells. These tumor cells home to and persist in the skin,producing a broad spectrum of clinical entities. Recent results of basic research on tumor biology and tumor immunology as well as molecular genetics of cutaneous T-cell lymphoma have fostered the development of new therapeutic approaches. Several clinical trials testing these targeted therapies have shown encouraging results. This article provides an overview of recent research developments and therapeutic strategies for cutaneous T-cell lymphoma.
皮肤T细胞淋巴瘤是一种成熟T细胞的结外非霍奇金淋巴瘤。这些肿瘤细胞归巢于皮肤并在其中持续存在，产生广泛的临床病变。最近关于皮肤T细胞淋巴瘤的肿瘤生物学、肿瘤免疫学以及分子遗传学的基础研究成果推动了新治疗方法的发展。几项测试这些靶向疗法的临床试验已显示出令人鼓舞的结果。本文概述了皮肤T细胞淋巴瘤的最新研究进展和治疗策略。
