Sebastian Aleksandra, Pehrson Christina, Larsson Lennart
Department of Laboratory Medicine, Section of Medical Microbiology, Lund University, Sölvegatan 23, 223 62, Lund, Sweden.
J Environ Monit. 2006 May;8(5):519-22. doi: 10.1039/b600706f. Epub 2006 Mar 27.
Exposure to environmental tobacco smoke (ETS) is an important worldwide public health issue. The present study demonstrates that cigarette smoke can be a major source of endotoxin (lipopolysaccharide, LPS) in indoor environments. Gas-chromatography/mass-spectrometry was used to determine 3-hydroxy fatty acids as markers of endotoxin in air-borne house dust in homes of smokers and non-smokers. Air concentrations of endotoxin were 4-63 times higher in rooms of smoking students than in identical rooms of non-smoking students. The fact that cigarette smoke contains large amounts of endotoxin may partly explain the high prevalence of respiratory disorders among smokers and may also draw attention to a hitherto neglected risk factor of ETS.
接触环境烟草烟雾（ETS）是一个全球性的重要公共卫生问题。本研究表明，香烟烟雾可能是室内环境中内毒素（脂多糖，LPS）的主要来源。采用气相色谱/质谱法测定吸烟者和非吸烟者家中空气中悬浮屋尘内毒素标志物3-羟基脂肪酸。吸烟学生房间内的内毒素空气浓度比不吸烟学生相同房间内的浓度高4至63倍。香烟烟雾含有大量内毒素这一事实可能部分解释了吸烟者中呼吸系统疾病的高患病率，也可能使人们关注到ETS一个迄今被忽视的危险因素。
