Grabowska M, Gumińska M, Ignacak J
Zakładu Biochemii Ogólnej Instytutu Biochemii Lekarskiej, Akademii Medycznej im. M. Kopernika, Krakowie.
Folia Med Cracov. 1991;32(1-2):103-10.
In the inhabitants of Chorzów, the most polluted town in the Upper Silesia, who showed increased urine fluoride excretion and elevated blood lead concentrations, the studies on erythrocyte membrane ATPase activities have been undertaken. The investigations showed the decrease in (Na,K)ATPase activity by about 70% in comparison with the average norm in 85% of workers of the Nitrogen Chemical Plant and the Slaughterhouse (groups A and M) and by about 50% in 65% of workers of the Steelworks (group S). The decrease in Mg-ATPase activity was smaller, by about 40% in 70% persons in groups A and M, and only by 20% in comparison with the control activity in 40% persons in group S. The correlation between the decrease in (Na,K)ATPase activity in vivo and the increase in urine fluoride excretion was demonstrated. Although the possibility of lead influence on this enzyme in vivo cannot be excluded, the correlation between the changes in ATPase activity and blood lead concentration was not found.
在位于上西里西亚污染最严重的城镇乔尔祖夫的居民中，他们的尿氟排泄增加且血铅浓度升高，针对这些居民开展了红细胞膜ATP酶活性的研究。调查显示，氮肥化工厂和屠宰场（A组和M组）85%的工人中，（钠，钾）ATP酶活性相较于平均标准降低了约70%；钢铁厂（S组）65%的工人中，该酶活性降低了约50%。镁 - ATP酶活性的降低幅度较小，A组和M组70%的人降低了约40%，而S组40%的人与对照活性相比仅降低了20%。体内（钠，钾）ATP酶活性的降低与尿氟排泄增加之间存在相关性。虽然不能排除铅在体内对该酶有影响的可能性，但未发现ATP酶活性变化与血铅浓度之间存在相关性。
