Liu Cheng-Tzu, Wong Pei-Linn, Lii Chong-Kuei, Hse Hunry, Sheen Lee-Yan
Department of Nutrition, Chun Shan Medical University, No. 110, Sec. 1, Chien Kuo N. Road, Taichung 402, Taiwan, ROC.
Food Chem Toxicol. 2006 Aug;44(8):1377-84. doi: 10.1016/j.fct.2005.07.013. Epub 2006 Mar 20.
We investigated the effects of garlic oil and diallyl disulfide (DADS) on glycemic control and renal function in rats with streptozotocin-induced diabetes. Rats received by gavage garlic oil (100 mg/kg body wt) or DADS (40 or 80 mg/kg body wt) every other day until 16 weeks after the induction of diabetes. The control rats were treated with corn oil only. Neither garlic oil nor DADS significantly affected fasting blood glucose concentrations throughout the investigation period. Garlic oil did not affect oral glucose tolerance in diabetes acutely but significantly improved oral glucose tolerance at 4, 8, 12, and 16 weeks and significantly ameliorated proteinuria at the end of 16 weeks. DADS did not significantly affect oral glucose tolerance or renal function. Diabetic rats fed 80 mg DADS/kg body wt had a significantly lower rate of body weight gain and a significantly lower ratio of muscle weight to body weight than did vehicle-treated diabetic rats. In conclusion, long-term treatment of diabetes with garlic oil can improve oral glucose tolerance and renal function in diabetes but not through the action of DADS. High doses of DADS may further complicate the metabolic disturbances in diabetes.
我们研究了大蒜油和二烯丙基二硫醚（DADS）对链脲佐菌素诱导的糖尿病大鼠血糖控制和肾功能的影响。大鼠每隔一天经口灌胃给予大蒜油（100毫克/千克体重）或DADS（40或80毫克/千克体重），直至糖尿病诱导后16周。对照大鼠仅用玉米油处理。在整个研究期间，大蒜油和DADS均未显著影响空腹血糖浓度。大蒜油对糖尿病大鼠的口服葡萄糖耐量急性无影响，但在4、8、12和16周时显著改善口服葡萄糖耐量，并在16周结束时显著改善蛋白尿。DADS对口服葡萄糖耐量或肾功能无显著影响。给予80毫克DADS/千克体重的糖尿病大鼠与接受载体处理的糖尿病大鼠相比，体重增加率显著降低，肌肉重量与体重之比显著降低。总之，大蒜油长期治疗糖尿病可改善糖尿病大鼠的口服葡萄糖耐量和肾功能，但并非通过DADS的作用。高剂量的DADS可能会使糖尿病的代谢紊乱进一步复杂化。
