Akutsu Tomoko, Sekiguchi Kazumasa, Ohmori Takeshi, Sakurada Koichi
Third Biology Section, Department of First Forensic Science, National Research Institute of Police Science, 6-3-1 Kashiwanoha, Kashiwa, Chiba 277-0882, Japan.
Chem Senses. 2006 Jul;31(6):557-63. doi: 10.1093/chemse/bjj060. Epub 2006 May 11.
The (E)-3-methyl-2-hexenoic acid (E3M2H), an axillary odor-related compound, is known to occur in Caucasians. The aims of this study were to clarify whether E3M2H contributes to axillary odor in Asians and to quantify and compare individual levels of E3M2H. Quantitative determination of E3M2H was performed by means of gas chromatography-mass spectrometry of sweat extracted from the axillary areas of T-shirts worn for 24 h by Japanese subjects. The amount of E3M2H was 15.9-34.6 nmol/ml in six of 30 subjects. Our method succeeded in quantitative analysis of E3M2H from axillary sweat collected individually; we also showed that E3M2H could be detected in Asians. This is the first report in which the amount of E3M2H in axillary sweat was quantified on an individual basis and compared to reveal individual differences. The results of this study indicate that E3M2H might contribute to axillary malodor in Asians as well as Caucasians.
（E）-3-甲基-2-己烯酸（E3M2H）是一种与腋窝气味相关的化合物，已知在白种人中存在。本研究的目的是阐明E3M2H是否导致亚洲人的腋窝气味，并对E3M2H的个体水平进行量化和比较。通过对日本受试者穿着24小时的T恤腋窝部位提取的汗液进行气相色谱-质谱分析，对E3M2H进行定量测定。30名受试者中有6人的E3M2H含量为15.9 - 34.6纳摩尔/毫升。我们的方法成功地对个体收集的腋窝汗液中的E3M2H进行了定量分析；我们还表明在亚洲人中可以检测到E3M2H。这是第一份对腋窝汗液中E3M2H含量进行个体量化并比较以揭示个体差异的报告。本研究结果表明，E3M2H可能在亚洲人和白种人中都导致腋窝异味。
