肾上腺皮质类固醇可增强由5-碘-2'-脱氧尿苷诱导培养的小鼠成纤维细胞产生C型病毒的能力。
Adrenal corticosteroids enhance production of type-C virus induced by 5-iodo-2'-deoxyuridine from cultured mouse fibroblasts.
作者信息
Paran M, Gallo R C, Richardson L S, Wu A M
出版信息
Proc Natl Acad Sci U S A. 1973 Aug;70(8):2391-5. doi: 10.1073/pnas.70.8.2391.
Abstract
Induction of RNA "tumor" viruses by 5-iodo-2'-deoxyuridine in mouse fibroblasts is stimulated 5- to 25-fold by glucogenic adrenal corticosteroids. Enhancement of virus production by the hormones is inhibited by low concentration of cordycepin, an inhibitor of poly(A) synthesis.
摘要
在小鼠成纤维细胞中，生糖肾上腺皮质激素可使5-碘-2'-脱氧尿苷诱导RNA“肿瘤”病毒的能力增强5至25倍。低浓度的虫草素（一种聚腺苷酸合成抑制剂）可抑制激素对病毒产生的增强作用。
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