Cordycepin inhibition of 3-methylcholanthrene-induced transformation in vitro.
作者信息
Price P J, Suk W A, Peters R L, Martin C E, Bellew T M, Huebner R J
出版信息
Proc Soc Exp Biol Med. 1975 Dec;150(3):650-3. doi: 10.3181/00379727-150-39098.
PMID:54927
Abstract
Cordycepin (3-deoxyadenosine), an inhibitor of poly (a) synthesis, was found to inhibit the induction of the endogenous type "C" RNA virus by 5-iodo-2'-deoxyuridine in a line of Fisher rat embryo cells (H43) grown in vitro, and when continuously incorporated into the medium at those same concentrations, it was found to protect the cells from transformation by the chemical carcinogen 3-methylcholanthrene.
摘要
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