Huang Qi, Zu Yukun, Fu Xiangning, Wu Tangchun
Department of Thoracic and Cardiac Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
J Huazhong Univ Sci Technolog Med Sci. 2005;25(6):693-5. doi: 10.1007/BF02896173.
The heat shock proteins (HSPs) 70 and HSP 27 expression in patients with non-small cell lung cancer (NSCLC) was studied and the relationship between HSP 70 and HSP 27 with the clinicopathological features of NSCLC was investigated. The expression of HSP 70 and HSP 27 was detected in tumor tissues from 60 patients with NSCLC by S-P immunohistochemistry. The findings were analyzed in combination with the histological types, histopathological differentiation, lymph node metastasis, patients' clinical stages, smoking history and gender. The results showed that of the 60 NSCLC tissue specimens studied, the immunoreactivity of HSP 70 and HSP 27 was detected in 47 (78.3%) and 43 (71.7%) specimens, respectively. A positive correlation was found between the overexpression of HSP 70 and HSP 27. The histopathological differentiation, lymph node metastasis, clinical stages and smoking history were correlated to the expression of HSP 70, but not to the expression of HSP 27. No statistical significance was observed in histological types and gender with respect to both HSP 70 and HSP 27 expression. It is suggested that the HSP 70 expression is a powerful and significant prognostic indicator and is related to histopathological differentiation, lymph node metastasis, patients' clinical stages, smoking history, whereas HSP 27 expression is not.
研究了非小细胞肺癌（NSCLC）患者中热休克蛋白（HSPs）70和HSP 27的表达情况，并探讨了HSP 70和HSP 27与NSCLC临床病理特征之间的关系。采用S-P免疫组织化学法检测60例NSCLC患者肿瘤组织中HSP 70和HSP 27的表达。结合组织学类型、组织病理学分化程度、淋巴结转移情况、患者临床分期、吸烟史和性别对结果进行分析。结果显示，在所研究的60例NSCLC组织标本中，分别在47例（78.3%）和43例（71.7%）标本中检测到HSP 70和HSP 27的免疫反应性。发现HSP 70和HSP 27的过表达之间呈正相关。组织病理学分化程度、淋巴结转移情况、临床分期和吸烟史与HSP 70的表达相关，但与HSP 27的表达无关。在组织学类型和性别方面，HSP 70和HSP 27的表达均未观察到统计学意义。提示HSP 70表达是一个有力且显著的预后指标，与组织病理学分化程度、淋巴结转移情况、患者临床分期、吸烟史有关，而HSP 27表达则不然。
