热休克蛋白作为肺癌的生物标志物。
Heat shock proteins as biomarkers of lung cancer.
机构信息
School of Biotechnology, Jawaharlal Nehru University, New Delhi, India.
出版信息
Cancer Biol Ther. 2020 Jun 2;21(6):477-485. doi: 10.1080/15384047.2020.1736482. Epub 2020 Mar 31.
Abstract
Heat shock proteins are known to be associated with a wide variety of human cancers including lung cancer. Overexpression of these molecular chaperones is linked with tumor survival, metastasis and anticancer drug resistance. In recent years, heat shock proteins are gaining much importance in the field of cancer research owing to their potential to be key determinants of cell survival and apoptosis. Lung cancer is one of the most common cancers diagnosed worldwide and the association of heat shock proteins in lung cancer diagnosis, prognosis and as drug targets remains unresolved. The aim of this review is to draw the importance of heat shock protein members; Hsp27, Hsp70, Hsp90, Hsp60 and their diagnostic and prognostic implications in lung cancer. Based on the available literature heat shock proteins can serve as biomarkers and anticancer drug targets in the management of lung cancer patients.
摘要
热休克蛋白已知与多种人类癌症有关，包括肺癌。这些分子伴侣的过度表达与肿瘤存活、转移和抗癌药物耐药性有关。近年来，由于热休克蛋白在细胞存活和细胞凋亡方面的潜在关键决定因素，它们在癌症研究领域越来越受到重视。肺癌是全球最常见的癌症之一，热休克蛋白在肺癌诊断、预后和作为药物靶点方面的关联仍未得到解决。本综述的目的是强调热休克蛋白成员（Hsp27、Hsp70、Hsp90、Hsp60）的重要性，以及它们在肺癌中的诊断和预后意义。基于现有文献，热休克蛋白可以作为生物标志物和抗癌药物靶点，用于肺癌患者的治疗。
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