Datta Kausik, Pirofski Liise-anne
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
FEMS Yeast Res. 2006 Jun;6(4):525-36. doi: 10.1111/j.1567-1364.2006.00073.x.
In the Damage-response framework of microbial pathogenesis, infectious diseases are one outcome of a host-microorganism interaction in a susceptible host. In cryptococcal disease, damage to the host is caused by Cryptococcus neoformans virulence determinants, the nature of the host response, or both. Further, the disease may be acute or reactivated from a latent state. Hence, a vaccine for C. neoformans would need to prevent disease resulting from either acute or reactivated infection. The evidence to support the development of a vaccine for C. neoformans that induces antibody-mediated immunity is discussed herein.
在微生物致病的损伤反应框架中，传染病是易感宿主中宿主与微生物相互作用的一种结果。在隐球菌病中，宿主损伤是由新型隐球菌的毒力决定因素、宿主反应的性质或两者共同引起的。此外，该疾病可能是急性的，也可能从潜伏状态重新激活。因此，针对新型隐球菌的疫苗需要预防急性感染或重新激活感染导致的疾病。本文讨论了支持开发诱导抗体介导免疫的新型隐球菌疫苗的证据。
