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小胶质细胞:中枢神经系统中的免疫网络。

Microglia: immune network in the CNS.

作者信息

Graeber M B, Streit W J

机构信息

Center for Neurologic Diseases, Harvard Medical School, Boston, MA.

出版信息

Brain Pathol. 1990 Sep;1(1):2-5. doi: 10.1111/j.1750-3639.1990.tb00630.x.

DOI:10.1111/j.1750-3639.1990.tb00630.x
PMID:1669689
Abstract

In recent years much progress has been made toward a better understanding of the nature and function of microglial cells. This review summarizes new developments and attempts to provide a perspective for future avenues to take in microglial research. Microglia are considered to play an active role in a variety of neurological diseases. Their function in forming a network of immune competent cells within the CNS is discussed.

摘要

近年来,在更好地理解小胶质细胞的性质和功能方面已经取得了很大进展。本综述总结了新的进展,并试图为小胶质细胞研究的未来方向提供一个视角。小胶质细胞被认为在多种神经系统疾病中发挥着积极作用。本文讨论了它们在中枢神经系统内形成免疫活性细胞网络中的功能。

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Microglia: immune network in the CNS.小胶质细胞:中枢神经系统中的免疫网络。
Brain Pathol. 1990 Sep;1(1):2-5. doi: 10.1111/j.1750-3639.1990.tb00630.x.
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Early activation of microglia as antigen-presenting cells correlates with T cell-mediated protection and repair of the injured central nervous system.作为抗原呈递细胞的小胶质细胞的早期激活与T细胞介导的对受损中枢神经系统的保护和修复相关。
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The role of microglia and astrocytes in CNS immune surveillance and immunopathology.小胶质细胞和星形胶质细胞在中枢神经系统免疫监视及免疫病理学中的作用。
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Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes.中枢神经系统抗原呈递细胞对T细胞反应的调节:小胶质细胞和星形胶质细胞的不同作用。
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Microglia: immunoregulatory cells in the central nervous system.小胶质细胞:中枢神经系统中的免疫调节细胞。
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Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared.通过流式细胞术分选从其他中枢神经系统巨噬细胞中分离出正常成年分枝状小胶质细胞。定义了表型差异,并比较了离体对髓鞘碱性蛋白反应性CD4+T细胞的直接抗原呈递。
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Do not judge a cell by its cover--diversity of CNS resident, adjoining and infiltrating myeloid cells in inflammation.勿以貌“髓”——炎症中中枢神经系统驻留、毗邻及浸润髓样细胞的多样性
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Molecular mechanisms of microglial activation.小胶质细胞激活的分子机制。
Adv Neuroimmunol. 1996;6(2):191-22. doi: 10.1016/0960-5428(96)00017-4.

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