Chiodi F, Fenyö E M
Department of Virology, Karolinska Institute, Stockholm, Sweden.
Brain Pathol. 1991 Apr;1(3):185-91. doi: 10.1111/j.1750-3639.1991.tb00658.x.
Three major characteristics of human immunodeficiency virus (HIV) infection define HIV as neurotropic. 1) Clinically, distinct neurological syndromes are associated with HIV infection and 2) presence of the virus as well as 3) pathological changes can be demonstrated in the central nervous system. Spread of HIV to the brain seems to be the general rule. Virus expression appears to be restricted during the asymptomatic period but increases with severity of HIV infection. Whether this reflects the emergence of virus variants with increased replicative capacity in brain cells has yet to be elucidated.
人类免疫缺陷病毒（HIV）感染的三个主要特征将HIV定义为嗜神经病毒。1）在临床上，特定的神经综合征与HIV感染相关，并且2）在中枢神经系统中可以证明病毒的存在以及3）病理变化。HIV扩散到大脑似乎是普遍规律。病毒表达在无症状期似乎受到限制，但随着HIV感染严重程度的增加而增加。这是否反映了在脑细胞中具有增强复制能力的病毒变体的出现尚待阐明。
