利什曼病的化学疗法第三部分：新型芳基取代萜烯基嘧啶作为抗利什曼原虫剂的合成与生物评价
Chemotherapy of leishmaniasis part III: synthesis and bioevaluation of novel aryl substituted terpenyl pyrimidines as antileishmanial agents.
作者信息
Chandra Naveen, Pandey Susmita, Suryawanshi S N, Gupta Suman
机构信息
Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow 226001, India.
出版信息
Eur J Med Chem. 2006 Jun;41(6):779-85. doi: 10.1016/j.ejmech.2006.02.004. Epub 2006 May 12.
PMID:16697490
Abstract
Some aryl substituted terpenyl pyrimidines 4 (a-p) have been synthesized using novel synthetic methods. The compounds were screened for in vitro antileishmanial activity against promastigotes. Compounds 4c, 4i and 4l showed IC(50) values as 35, 35 and 25 microg ml(-1).
摘要
一些芳基取代的萜烯基嘧啶4（a - p）已采用新型合成方法合成。对这些化合物进行了体外抗前鞭毛体利什曼原虫活性筛选。化合物4c、4i和4l的半数抑制浓度（IC50）值分别为35、35和25微克/毫升。
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