一些新型萜烯基嘧啶的合成及其抗利什曼原虫活性
Synthesis and antileishmanial profile of some novel terpenyl pyrimidines.
作者信息
Pandey Susmita, Suryawanshi S N, Gupta Suman, Srivastava V M L
机构信息
Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India.
出版信息
Eur J Med Chem. 2004 Nov;39(11):969-73. doi: 10.1016/j.ejmech.2004.03.007.
PMID:15501546
Abstract
Some novel terpenyl pyrimidine derivatives 2(a-d) and 6(a-b) have been synthesised from alpha/beta-ionone keteneacetals 1 and 5. The terpenyl pyrimidine 2e has been synthesised from beta-ionone 3 in two steps in quantitative yield. The pyrimidine derivatives were screened for in-vivo antilesihmanial activity. The compounds 2d, 2e, 6a and 6b showed promising in-vivo antileishmanial activity.
摘要
一些新型萜烯基嘧啶衍生物2（a - d）和6（a - b）已由α/β-紫罗兰酮乙烯酮缩醛1和5合成。萜烯基嘧啶2e由β-紫罗兰酮3分两步合成，产率为定量。对嘧啶衍生物进行了体内抗利什曼原虫活性筛选。化合物2d、2e、6a和6b显示出有前景的体内抗利什曼原虫活性。
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