利什曼病的化疗 第二部分：作为抗利什曼原虫剂的取代芳基乙烯酮二硫代缩醛的合成与生物评价
Chemotherapy of leishmaniasis part II: synthesis and bioevaluation of substituted arylketene dithioacetals as antileishmanial agents.
作者信息
Pandey Susmita, Suryawanshi S N, Gupta Suman, Srivastava V M L
机构信息
Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India.
出版信息
Eur J Med Chem. 2005 Aug;40(8):751-6. doi: 10.1016/j.ejmech.2005.02.007.
PMID:15907348
Abstract
Some novel aryl substituted ketene dithioacetals have been synthesized using novel synthetic methods. The compounds were screened against Leishmania donovani in hamsters for their activity profile. Some of the compounds inhibited 50-65% parasite growth at 50 mg kg(-1) x 5 days.
摘要
一些新型芳基取代的烯酮二硫代缩醛已通过新型合成方法合成。这些化合物在仓鼠体内针对杜氏利什曼原虫进行了活性筛选。其中一些化合物在50 mg kg(-1)×5天的剂量下可抑制50%-65%的寄生虫生长。
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