Coll Blai, Parra Sandra, Alonso-Villaverde Carlos, de Groot Eric, Aragonés Gerard, Montero Manuel, Tous Monica, Camps Jordi, Joven Jorge, Masana Lluis
Servei de Medicina Interna, Hospital Universitari Sant Joan, Reus, Spain.
Cytokine. 2006 Apr;34(1-2):51-5. doi: 10.1016/j.cyto.2006.03.013. Epub 2006 May 12.
Individuals with HIV-1 infection are at increased risk for cardiovascular events, and lipodystrophy is generally associated with pro-atherogenic metabolic disturbances. We conducted a case-control study to assess the presence of sub-clinical atherosclerosis in HIV-1-infected patients with or without lipodystrophy (LD) and to evaluate the influence of monocyte chemoattractant protein-1 (MCP-1) on the development of both carotid atherosclerosis and LD. The study population consisted of 43 patients with LD and 86 patients without LD. We determined carotid intima-media thickness (IMT), MCP-1 concentrations in plasma, and MCP-1 genotype (presence or absence of the -2518G allele). HIV-1-infected patients with LD showed increased risk (OR=3.71, 95% CI=1.10-12.47, p=0.03) for sub-clinical atherosclerosis, and MCP-1 plasma concentration was significantly correlated with IMT in these patients (Pearson=0.31, p=0.03). Furthermore, presence of LD was a determinant for MCP-1 plasma concentration (beta=0.18, p=0.05). In summary, HIV-1-infected patients with clinically manifest LD are at higher risk for atherosclerosis and our observations support the relationship between inflammation and atherosclerotic disease.
感染HIV-1的个体发生心血管事件的风险增加，脂肪代谢障碍通常与促动脉粥样硬化的代谢紊乱有关。我们进行了一项病例对照研究，以评估有无脂肪代谢障碍（LD）的HIV-1感染患者亚临床动脉粥样硬化的存在情况，并评估单核细胞趋化蛋白-1（MCP-1）对颈动脉粥样硬化和LD发展的影响。研究人群包括43例有LD的患者和86例无LD的患者。我们测定了颈动脉内膜中层厚度（IMT）、血浆中MCP-1浓度以及MCP-1基因型（-2518G等位基因的有无）。有LD的HIV-1感染患者发生亚临床动脉粥样硬化的风险增加（OR=3.71，95%CI=1.10-12.47，p=0.03），并且这些患者的MCP-1血浆浓度与IMT显著相关（Pearson=0.31，p=0.03）。此外，LD的存在是MCP-1血浆浓度的一个决定因素（β=0.18，p=0.05）。总之，有临床明显LD的HIV-1感染患者发生动脉粥样硬化的风险更高，我们的观察结果支持炎症与动脉粥样硬化疾病之间的关系。
