Pennello Anthony, Taylor Justin, Matlack Robin, Karp Jonathan, Riggs James
Department of Biology, Rider University, Lawrenceville, NJ 08648-3099, USA.
Dev Comp Immunol. 2006;30(12):1181-90. doi: 10.1016/j.dci.2006.03.007. Epub 2006 Apr 27.
Analysis of the immune system of spiny mice (Acomys cahirinus) has been limited. Originally grouped with Mus, Acomys has recently been placed closer to Meriones (gerbils). This study compared immunity in Acomys, Mus, and Meriones. Lymphocytes from all rodents examined proliferated in response to mitogen and superantigen stimulation. Only Mus T cells responded to anti-CD3 stimulation. Acomys, like Meriones, and Mus that express xid, did not respond to thymus-independent type 2 antigens. Flow cytometric analyses revealed that T cell-specific MAbs did not bind Acomys or Meriones lymphocytes. The B cell-specific anti-CD45R (B220) MAb detected all rodent B cells and revealed the absence of a CD45R(lo) subset in the peritoneal cavity of Acomys and Meriones. Bone marrow from Acomys and Meriones failed to reconstitute B cell function in SCID mice. Thus, in terms of immunity, Acomys appears to be more similar to Meriones than Mus.
对刺毛鼠（埃及刺毛鼠）免疫系统的分析一直很有限。刺毛鼠最初与小家鼠归为一类，最近被认为与长爪沙鼠（沙鼠）关系更近。本研究比较了刺毛鼠、小家鼠和长爪沙鼠的免疫情况。所有受试啮齿动物的淋巴细胞在有丝分裂原和超抗原刺激下均有增殖。只有小家鼠的T细胞对抗CD3刺激有反应。刺毛鼠和长爪沙鼠以及表达xid的小家鼠一样，对非胸腺依赖性2型抗原无反应。流式细胞术分析显示，T细胞特异性单克隆抗体不与刺毛鼠或长爪沙鼠的淋巴细胞结合。B细胞特异性抗CD45R（B220）单克隆抗体可检测到所有啮齿动物的B细胞，并显示刺毛鼠和长爪沙鼠腹腔中不存在CD45R(lo)亚群。刺毛鼠和长爪沙鼠的骨髓无法在严重联合免疫缺陷小鼠中重建B细胞功能。因此，在免疫方面，刺毛鼠似乎与长爪沙鼠比与小家鼠更相似。
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