Yehudai D, Shoenfeld Y, Toubi E
Bnai-Zion Medical Center Affiliated with the Technion Faculty of Medicine, Division of Clinical Immunology and Allergy, Haifa, Israel.
Autoimmunity. 2006 Mar;39(2):153-8. doi: 10.1080/08916930500499599.
Autoimmune sensorineural hearing loss (ASNHL) is a clinical syndrome that typically produces a bilateral rapidly progressive hearing loss. Autoantibodies and autoreactive T cells have been implicated in the etiopathogenesis of ASNHL. However, the identity of a specific or highly relevant inner-ear self-antigen is still required. In recent years, a role for antiphospholipid antibodies has been also suggested, assuming sudden/progressive hearing loss to be part of the primary antiphospholipid syndrome (APS). In this review, we address the need for specific diagnostic tools in order to establish an autoimmune origin for hearing loss. Moreover, the decision of whether anti-inflammatory drugs or anti-coagulation should be given is also discussed.
自身免疫性感音神经性听力损失（ASNHL）是一种临床综合征，通常会导致双侧快速进行性听力损失。自身抗体和自身反应性T细胞与ASNHL的发病机制有关。然而，仍需要确定一种特定的或高度相关的内耳自身抗原。近年来，也有人提出抗磷脂抗体的作用，认为突发性/进行性听力损失是原发性抗磷脂综合征（APS）的一部分。在这篇综述中，我们阐述了需要特定的诊断工具来确定听力损失的自身免疫起源。此外，还讨论了是否应给予抗炎药物或抗凝药物的决策。
