B组柯萨奇病毒致糖尿病表型与复制效率相关。
Group B coxsackievirus diabetogenic phenotype correlates with replication efficiency.
作者信息
Kanno Toru, Kim Kisoon, Kono Ken, Drescher Kristen M, Chapman Nora M, Tracy Steven
机构信息
Enterovirus Research Laboratory, Department of Pathology and Microbiology, University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, NE 68198-6495, USA.
出版信息
J Virol. 2006 Jun;80(11):5637-43. doi: 10.1128/JVI.02361-05.
Abstract
Group B coxsackieviruses can initiate rapid onset type 1 diabetes (T1D) in old nonobese diabetic (NOD) mice. Inoculating high doses of poorly pathogenic CVB3/GA per mouse initiated rapid onset T1D. Viral protein was detectable in islets shortly after inoculation in association with beta cells as well as other primary islet cell types. The virulent strain CVB3/28 replicated to higher titers more rapidly than CVB3/GA in the pancreas and in established beta cell cultures. Exchange of 5'-nontranslated regions between the two CVB3 strains demonstrated a variable impact on replication in beta cell cultures and suppression of in vivo replication for both strains. While any CVB strain may be able to induce T1D in prediabetic NOD mice, T1D onset is linked both to the viral replication rate and infectious dose.
摘要
B组柯萨奇病毒可在老年非肥胖糖尿病（NOD）小鼠中引发快速发病的1型糖尿病（T1D）。每只小鼠接种高剂量致病性较弱的CVB3/GA可引发快速发病的T1D。接种后不久，在胰岛中可检测到病毒蛋白，其与β细胞以及其他主要胰岛细胞类型相关。在胰腺和已建立的β细胞培养物中，强毒株CVB3/28比CVB3/GA更快地复制到更高滴度。两种CVB3毒株之间5'非翻译区的交换对β细胞培养物中的复制以及两种毒株的体内复制抑制都有不同影响。虽然任何CVB毒株都可能能够在糖尿病前期NOD小鼠中诱导T1D，但T1D的发病与病毒复制率和感染剂量都有关联。
相似文献
1
Group B coxsackievirus diabetogenic phenotype correlates with replication efficiency.B组柯萨奇病毒致糖尿病表型与复制效率相关。
J Virol. 2006 Jun;80(11):5637-43. doi: 10.1128/JVI.02361-05.
2
Toward testing the hypothesis that group B coxsackieviruses (CVB) trigger insulin-dependent diabetes: inoculating nonobese diabetic mice with CVB markedly lowers diabetes incidence.为了验证B组柯萨奇病毒（CVB）引发胰岛素依赖型糖尿病这一假说：给非肥胖糖尿病小鼠接种CVB可显著降低糖尿病发病率。
J Virol. 2002 Dec;76(23):12097-111. doi: 10.1128/jvi.76.23.12097-12111.2002.
3
Coxsackievirus B3 infection and type 1 diabetes development in NOD mice: insulitis determines susceptibility of pancreatic islets to virus infection.柯萨奇病毒B3感染与非肥胖糖尿病（NOD）小鼠1型糖尿病的发生：胰岛炎决定胰腺胰岛对病毒感染的易感性。
Virology. 2004 Nov 24;329(2):381-94. doi: 10.1016/j.virol.2004.06.049.
4
Coxsackievirus infections and NOD mice: relevant models of protection from, and induction of, type 1 diabetes.柯萨奇病毒感染与非肥胖糖尿病（NOD）小鼠：预防和诱发1型糖尿病的相关模型
Ann N Y Acad Sci. 2007 Apr;1103:143-51. doi: 10.1196/annals.1394.009. Epub 2007 Mar 21.
5
Group B coxsackievirus myocarditis and pancreatitis: connection between viral virulence phenotypes in mice.B组柯萨奇病毒心肌炎与胰腺炎：小鼠病毒毒力表型之间的联系
J Med Virol. 2000 Sep;62(1):70-81. doi: 10.1002/1096-9071(200009)62:1<70::aid-jmv11>3.0.co;2-r.
6
Antiviral treatment of Coxsackie B virus infection in human pancreatic islets.人胰岛中柯萨奇B病毒感染的抗病毒治疗
Antiviral Res. 2007 Apr;74(1):65-71. doi: 10.1016/j.antiviral.2006.12.001. Epub 2006 Dec 29.
7
Secondary heterotypic versus homotypic infection by Coxsackie B group viruses: impact on early and late histopathological lesions and virus genome prominence.柯萨奇B组病毒的继发性异型与同型感染：对早期和晚期组织病理学病变及病毒基因组突出性的影响
Cardiovasc Pathol. 1999 Mar-Apr;8(2):93-102. doi: 10.1016/s1054-8807(98)00025-8.
8
Persistent infection of human pancreatic islets by coxsackievirus B is associated with alpha interferon synthesis in beta cells.柯萨奇病毒B对人胰岛的持续感染与β细胞中α干扰素的合成有关。
J Virol. 2000 Nov;74(21):10153-64. doi: 10.1128/jvi.74.21.10153-10164.2000.
9
Pathogenesis of virus-induced diabetes in mice.小鼠中病毒诱导的糖尿病的发病机制。
J Infect Dis. 1995 May;171(5):1131-8. doi: 10.1093/infdis/171.5.1131.
10
Mutation variants generated from nonvirulent coxsackievirus B3 acquire virulence phenotypes by active virus replication.由无毒力的柯萨奇病毒B3产生的突变变体通过活跃的病毒复制获得毒力表型。
Intervirology. 2007;50(6):447-53. doi: 10.1159/000115950. Epub 2008 Feb 12.
引用本文的文献
1
Mt10 Vaccine Protects Diversity Outbred Mice from CVB3 Infection by Producing Virus-Specific Neutralizing Antibodies and Diverse Antibody Isotypes.Mt10疫苗通过产生病毒特异性中和抗体和多种抗体亚型保护远交系小鼠免受柯萨奇病毒B3（CVB3）感染。
Vaccines (Basel). 2024 Mar 4;12(3):266. doi: 10.3390/vaccines12030266.
2
Viruses and Type 1 Diabetes: From Enteroviruses to the Virome.病毒与1型糖尿病：从肠道病毒到病毒组
Microorganisms. 2021 Jul 16;9(7):1519. doi: 10.3390/microorganisms9071519.
3
The virome in early life and childhood and development of islet autoimmunity and type 1 diabetes: A systematic review and meta-analysis of observational studies.生命早期和儿童时期的病毒组与胰岛自身免疫和 1 型糖尿病的发展：观察性研究的系统评价和荟萃分析。
Rev Med Virol. 2021 Sep;31(5):1-14. doi: 10.1002/rmv.2209. Epub 2020 Dec 30.
4
Genetic Susceptibility of the Host in Virus-Induced Diabetes.宿主在病毒诱导的糖尿病中的遗传易感性。
Microorganisms. 2020 Jul 27;8(8):1133. doi: 10.3390/microorganisms8081133.
5
Innate Viral Sensor MDA5 and Coxsackievirus Interplay in Type 1 Diabetes Development.先天性病毒传感器MDA5与柯萨奇病毒在1型糖尿病发生中的相互作用
Microorganisms. 2020 Jul 3;8(7):993. doi: 10.3390/microorganisms8070993.
6
Higher abundance of enterovirus A species in the gut of children with islet autoimmunity.肠病毒 A 种在胰岛自身免疫儿童肠道中的丰度更高。
Sci Rep. 2019 Feb 11;9(1):1749. doi: 10.1038/s41598-018-38368-8.
7
Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes.肠病毒疫苗接种和抗病毒疗法在人类 1 型糖尿病中的应用原理。
Diabetologia. 2019 May;62(5):744-753. doi: 10.1007/s00125-019-4811-7. Epub 2019 Jan 23.
8
MafA Expression Preserves Immune Homeostasis in Human and Mouse Islets.MafA表达维持人和小鼠胰岛中的免疫稳态。
Genes (Basel). 2018 Dec 18;9(12):644. doi: 10.3390/genes9120644.
9
Paradigm Shift in Life Sciences.生命科学中的范式转变。
Osong Public Health Res Perspect. 2018 Jun;9(3):93-94. doi: 10.24171/j.phrp.2018.9.3.01.
10
In silico and ex vivo approaches indicate immune pressure on capsid and non-capsid regions of coxsackie B viruses in the human system.基于计算机和体外方法研究表明，人类柯萨奇 B 病毒的衣壳和非衣壳区会受到免疫压力的影响。
PLoS One. 2018 Jun 20;13(6):e0199323. doi: 10.1371/journal.pone.0199323. eCollection 2018.
本文引用的文献
1
Enterovirus surveillance--United States, 2002-2004.2002 - 2004年美国肠道病毒监测
MMWR Morb Mortal Wkly Rep. 2006 Feb 17;55(6):153-6.
2
Recombination in circulating Human enterovirus B: independent evolution of structural and non-structural genome regions.人肠道病毒B型流行株的重组：结构基因组区域与非结构基因组区域的独立进化
J Gen Virol. 2005 Dec;86(Pt 12):3281-3290. doi: 10.1099/vir.0.81264-0.
3
Enterovirus RNA sequences in sera of schoolchildren in the general population and their association with type 1-diabetes-associated autoantibodies.普通人群中在校儿童血清中的肠道病毒RNA序列及其与1型糖尿病相关自身抗体的关联。
J Med Microbiol. 2005 Sep;54(Pt 9):879-883. doi: 10.1099/jmm.0.46015-0.
4
Simultaneous type 1 diabetes onset in mother and son coincident with an enteroviral infection.母亲和儿子同时发生1型糖尿病，与肠道病毒感染同时出现。
J Clin Virol. 2005 Jun;33(2):158-67. doi: 10.1016/j.jcv.2004.12.009.
5
Islet cell related antibodies and type 1 diabetes associated with echovirus 30 epidemic: a case report.与肠道病毒30型流行相关的胰岛细胞相关抗体和1型糖尿病：一例报告
J Med Virol. 2005 Jul;76(3):373-7. doi: 10.1002/jmv.20368.
6
Characterization of an infectious cDNA copy of the genome of a naturally occurring, avirulent coxsackievirus B3 clinical isolate.一株自然存在的无毒柯萨奇病毒B3临床分离株基因组感染性cDNA拷贝的特性分析
J Gen Virol. 2005 Jan;86(Pt 1):197-210. doi: 10.1099/vir.0.80424-0.
7
Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes.满意度（未必）有保证：重新评估1型糖尿病动物模型的应用
Nat Rev Immunol. 2004 Dec;4(12):989-97. doi: 10.1038/nri1502.
8
Coxsackievirus B3 infection and type 1 diabetes development in NOD mice: insulitis determines susceptibility of pancreatic islets to virus infection.柯萨奇病毒B3感染与非肥胖糖尿病（NOD）小鼠1型糖尿病的发生：胰岛炎决定胰腺胰岛对病毒感染的易感性。
Virology. 2004 Nov 24;329(2):381-94. doi: 10.1016/j.virol.2004.06.049.
9
Enterovirus infections with beta-cell tropic strains are frequent in siblings of children diagnosed with type 1 diabetes children and in association with elevated levels of GAD65 antibodies.在被诊断为1型糖尿病儿童的兄弟姐妹中，肠道病毒与β细胞嗜性毒株的感染很常见，且与GAD65抗体水平升高有关。
J Med Virol. 2004 Jul;73(3):450-9. doi: 10.1002/jmv.20111.
10
RNA recombination plays a major role in genomic change during circulation of coxsackie B viruses.在柯萨奇B病毒传播过程中，RNA重组在基因组变化方面起着主要作用。
J Virol. 2004 Mar;78(6):2948-55. doi: 10.1128/jvi.78.6.2948-2955.2004.
Zotero 插件