Venturini Massimo, Fiorina Paolo, Maffi Paola, Losio Claudio, Vergani Andrea, Secchi Antonio, Del Maschio Alessandro
Department of Radiology, San Raffaele Scientific Institute, Milan and Universita' Vita e Salute-San Raffaele, Milan, Italy.
Transplantation. 2006 May 15;81(9):1274-7. doi: 10.1097/01.tp.0000208631.63235.6a.
Little information is currently available about the role of islet transplantation alone (ITA) on the retinal microcirculation. Our purpose was to investigate with color-Doppler-imaging the effect of ITA after one year on the blood flow velocities of central retinal artery and vein. Central retinal arteries and veins of both eyes of 10 ITA patients were evaluated with color-Doppler-imaging before and one year after transplant. Peak systolic velocity (psv), end diastolic velocity (edv) for arteries and maximum velocity (maxv), minimum velocity (minv) for veins were recorded and compared with a control group of type 1 diabetic patients. At one year, a statistically significant increase of blood flow velocities of central retinal arteries (psv: 6.09+/-0.46 vs. 10.12+/-1.20 cm/s, P=0.01) and veins (maxv: 3.12+/-0.28 vs. 6.12+/-1.00 cm/s, P=0.01) was found only in the ITA patients. An early, significant increase of arterial and venous retinal blood flow velocities was found after ITA.
目前关于单纯胰岛移植（ITA）对视网膜微循环作用的信息很少。我们的目的是通过彩色多普勒成像研究ITA术后一年对视网膜中央动脉和静脉血流速度的影响。对10例ITA患者双眼的视网膜中央动脉和静脉在移植前及移植后一年进行彩色多普勒成像评估。记录动脉的收缩期峰值速度（psv）、舒张末期速度（edv）以及静脉的最大速度（maxv）、最小速度（minv），并与1型糖尿病患者对照组进行比较。在一年时，仅在ITA患者中发现视网膜中央动脉（psv：6.09±0.46 vs. 10.12±1.20 cm/s，P = 0.01）和静脉（maxv：3.12±0.28 vs. 6.12±1.00 cm/s，P = 0.01）的血流速度有统计学意义的增加。在ITA术后发现动脉和静脉视网膜血流速度早期有显著增加。
